骨巨细胞瘤是一种常见的侵袭性骨骺骨肿瘤，最常通过手术治疗。自然病程和表现有经典描述，但组织病理学却知之甚少。病灶内刮除术是治疗的主要手段，但辅助剂和空洞填充方式的使用存在显着差异。目前还没有就治疗达成一致的金标准，目前正在使用多种技术。鉴于其位置，继发性骨关节炎是一种已知的长期并发症。这篇综述探讨了巨细胞瘤的自然史、治疗选择和并发症，以及骨关节炎的后续发展。关节置换术通常适用于继发性骨关节炎，尽管其疗效的数据有限。进一步的方向可能集中在改进的药物治疗以及改进的关节成形术技术上。© 2024 作者。

Giant cell tumor of bone is a commonly encountered aggressive epiphyseal bone tumor, most often treated surgically. The natural history and presentation are classically described but the histopathology is poorly understood. Intralesional curettage is the mainstay of treatment, but there is significant variation in the use of adjuvant and cavity filling modalities. No gold standard has been agreed upon for treatment, and a variety of techniques are currently in use. Given its location, secondary osteoarthritis is a known long-term complication. This review examines the natural history of giant cell tumors, treatment options and complications, and subsequent development of osteoarthritis. Arthroplasty is usually indicated for secondary osteoarthritis although data is limited on its efficacy. Further directions will likely center on improved pharmacological treatments as well as improved arthroplasty techniques.© 2024 The Authors.