为了评估接触低水平苯的职业人群的白血病风险。使用线性多阶段（LMS）模型拟合了中国苯队列研究的白血病发病率数据。对中国工厂 98 名接触苯的工人进行了个体苯暴露水平、尿 S-苯硫醇酸 (S-PMA) 和反式、反式粘康酸 (t, t-MA) 的测量。通过对累积苯浓度的四分位数进行四舍五入，将受试者分为四组（分别为< 3、3-5、5-12、≥12mg/m3·年）。使用LMS模型评估苯诱发白血病的风险，并使用EPA模型和新加坡半定量风险评估模型对结果进行验证。四个暴露组中白血病风险与累积浓度的增加呈正相关（ LMS模型显示，过量白血病风险分别为4.34、4.37、4.44和5.52 × 10-4；Ptrend < 0.0001)。我们还发现，与 S-PMA 相比，LMS 模型中使用尿 t、t-MA 估计的白血病风险与通过空气中苯估计的风险更相似。 LMS模型估算的白血病风险在所有浓度下均与新加坡半定量风险评估模型一致，在高浓度（5-12，≥12mg/m3·年）下与EPA模型一致，同时超过了EPA模型低浓度（< 3 和 3-5 mg/m3·年）。然而，在所有四个苯暴露组中，这三个模型估计的白血病风险都超过了 EPA 设定的致癌风险最低可接受限值 1 × 10-6。这项研究证明了源自中国的 LMS 模型的实用性。苯队列评估与低水平苯暴露相关的白血病风险，并表明累积浓度低于 3 mg/m3·year 时可能出现白血病风险。版权所有 © 2024 Jin, Zhu, Wu, Li, Wang, Cheng, Li, Huang和兴。

To assess leukemia risk in occupational populations exposed to low levels of benzene.Leukemia incidence data from the Chinese Benzene Cohort Study were fitted using the Linearized multistage (LMS) model. Individual benzene exposure levels, urinary S-phenylmercapturic acid (S-PMA) and trans, trans-muconic acid (t, t-MA) were measured among 98 benzene-exposed workers from factories in China. Subjects were categorized into four groups by rounding the quartiles of cumulative benzene concentrations (< 3, 3-5, 5-12, ≥12 mg/m3·year, respectively). The risk of benzene-induced leukemia was assessed using the LMS model, and the results were validated using the EPA model and the Singapore semi-quantitative risk assessment model.The leukemia risks showed a positive correlation with increasing cumulative concentration in the four exposure groups (excess leukemia risks were 4.34, 4.37, 4.44 and 5.52 × 10-4, respectively; Ptrend < 0.0001) indicated by the LMS model. We also found that the estimated leukemia risk using urinary t, t-MA in the LMS model was more similar to those estimated by airborne benzene compared to S-PMA. The leukemia risk estimated by the LMS model was consistent with both the Singapore semi-quantitative risk assessment model at all concentrations and the EPA model at high concentrations (5-12, ≥12 mg/m3·year), while exceeding the EPA model at low concentrations (< 3 and 3-5 mg/m3·year). However, in all four benzene-exposed groups, the leukemia risks estimated by these three models exceeded the lowest acceptable limit for carcinogenic risk set by the EPA at 1 × 10-6.This study demonstrates the utility of the LMS model derived from the Chinese benzene cohort in assessing leukemia risk associated with low-level benzene exposure, and suggests that leukemia risk may occur at cumulative concentrations below 3 mg/m3·year.Copyright © 2024 Jin, Zhu, Wu, Li, Wang, Cheng, Li, Huang and Xing.