消化系统肿瘤是全世界癌症相关死亡的主要原因。尽管正在进行研究，但我们对其机制和治疗的了解仍然不足。一种有前途的临床应用工具是使用胃肠道肿瘤类器官，它是一种重要的体外模型。肿瘤类器官表现出与患者肿瘤相似的基因型，并有效地模拟各种生物过程，包括组织更新、干细胞和生态位功能，以及组织对药物、突变或损伤的反应。因此，它们对于药物筛选、开发新药、评估患者结果和支持免疫治疗很有价值。此外，创新材料和技术可用于优化肿瘤类器官培养系统。消化系统肿瘤类器官的几种应用已经被描述，并在相关方面显示出有希望的结果。在这篇综述中，我们讨论了该消化系统肿瘤模型的当前进展、局限性和前景。© 作者 2024。

Digestive system tumors are the leading cause of cancer-related deaths worldwide. Despite ongoing research, our understanding of their mechanisms and treatment remain inadequate. One promising tool for clinical applications is the use of gastrointestinal tract tumor organoids, which serve as an important in vitro model. Tumor organoids exhibit a genotype similar to the patient's tumor and effectively mimic various biological processes, including tissue renewal, stem cell, and ecological niche functions, and tissue response to drugs, mutations, or injury. As such, they are valuable for drug screening, developing novel drugs, assessing patient outcomes, and supporting immunotherapy. In addition, innovative materials and techniques can be used to optimize tumor organoid culture systems. Several applications of digestive system tumor organoids have been described and have shown promising results in related aspects. In this review, we discuss the current progress, limitations, and prospects of this model for digestive system tumors.© The Author(s) 2024.