登革热感染可以引发免疫反应，导致炎症反应，作为保护宿主的防御机制。登革热感染导致促炎细胞因子的释放增加，包括肿瘤坏死因子-α (TNF-α)、白介素-1β (IL-1β) 和白细胞介素-6 (IL-6)。这三种细胞因子已被证明与血小板减少症和血浆渗漏的发生有关，而血浆渗漏又与疾病的严重程度有关。本研究旨在研究 faloak (Sterculia fourrifida R. Br) 茎皮对 TNF-α、感染登革热（特别是 DENV-3）的 Wistar 大鼠中的 IL-1β 和 IL-6 水平。将 27 只年龄为 2-3 个月、体重为 200-300 g 的雄性 Wistar 大鼠（Rattusnorvegicus）分为三个不同组：健康组、登革热组和治疗组（登革热感染和提取物）。登革热组和治疗组的大鼠均通过腹膜内途径注射DENV-3，滴度为105 pfu，剂量为0.8 cc。 DENV-3的增殖是使用C6/36细胞开始的，并且经历了四次传代。通过鼻胃管口服提取物，剂量为 1,500 mg/kg 体重，每天一次，持续 7 天。健康组在第一天采血，登革热组和治疗组分别在第五天和第八天采血。与健康组相比，登革热组和治疗组在第5天的TNF-α水平存在显着差异。感染后。事后分析显示，登革热治疗组和登革热健康组之间存在统计学显着差异。与健康组相比，感染后第 5 天和第 8 天，登革热组和健康组的 IL-1β 水平存在显着差异。治疗组在第 5 天和第 8 天的 IL-6 水平下降幅度小于登革热组。然而，没有观察到统计学上的显着差异。 S. fourrifida 的茎皮显示出作为登革热感染抗炎剂的潜力，特别是其降低 TNF-α 和 IL-1β 水平的能力。

Dengue infection can trigger an immunological response that results in an inflammatory reaction, which acts as a defensive mechanism to protect the host. Dengue infection leads to an elevation in the release of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). These three cytokines have been shown to correlate with the development of thrombocytopenia and plasma leakage, which is related to the severity of the disease.This study aims to investigate the effect of faloak (Sterculia quadrifida R. Br) stem bark on TNF-α, IL-1β, and IL-6 levels in Wistar rats infected with dengue, specifically DENV-3.A group of 27 male Wistar rats (Rattus norvegicus) aged 2-3 months and weighting 200-300 g were divided into three distinct groups: healthy, dengue, and treatment (dengue infection and extract) groups. The rats in both the dengue and treatment groups were administered an injection of DENV-3 with a titer of 105 pfu at a dosage of 0.8 cc via the intraperitoneal route. The propagation of DENV-3 was initiated using C6/36 cells, and it underwent four passages. The extract was administered orally via a nasogastric tube at a dosage of 1,500 mg/kg body weight once daily for 7 days. The healthy group underwent blood sampling on the first day, whereas the dengue and therapy groups underwent blood sampling on the fifth and eighth, respectively.Compared with the healthy group, TNF-α levels in the dengue and treatment groups showed significant differences on day 5 post-infection. The post hoc analysis revealed a statistically significant difference between the dengue-treatment and dengue-healthy groups. The IL-1β levels in the dengue and healthy groups significantly differed on days 5 and 8 post-infection compared to the healthy group. The treatment group had less of a decrease in IL-6 levels on days 5 and 8 than the dengue group. However, no statistically significant differences were observed.The stem bark of S. quadrifida shows potential as an anti-inflammatory agent in dengue infections, particularly in its ability to decrease levels of TNF-α and IL-1β.