化疗引起的周围神经毒性（CIPN）是实体癌和血液癌治疗中常用的化疗方案的主要并发症之一。鉴于患者抗肿瘤治疗中 CIPN 发生率较高且抗氧化剂研究有限，本研究旨在探讨水飞蓟 (SM) 对顺铂诱发的周围神经病变的影响。这项双盲随机临床试验研究对 60 名患者进行了研究。 2019-2020 年在伊斯法罕 Seyyed-o-Shohada 医院接受顺铂化疗的癌症患者。将患者分为干预（SM治疗）和安慰剂两个平行组，对干预前后的患者完成DN4（Douleur neuropathique 4题）和CIPNAT（化疗引起的周围神经病变评估工具）并进行比较干预组研究前后DN4评分均值分别为1.76±1.24和2.07±2.03（P=0.38），对照组为1.41±1.28±3.11±2.86 ，分别（P = 0.012）。干预组的平均 CIPNAT 评分为 5.93 ± 3.65 和 4.20 ± 3.23 (P = 0.01)，对照组的平均 CIPNAT 评分为 4.20 ± 4.22 和 4.16 ± 4.03 (P = 0.39)。根据我们的数据，SM 是一种有效的治疗方法。减少周围神经病变的药剂。 SM 的使用与周围神经病变评分降低相关，并且对接受顺铂化疗的患者有帮助。版权所有：© 2024 Advanced Biomedical Research。

Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the major complications of chemotherapy regimens commonly used in the treatment of solid and hematologic cancers. Given the high incidence of CIPN in antitumor therapies in patients and limited studies on antioxidants, this study was aimed to investigate the effect of Silybum marianum (SM) on cisplatin-induced peripheral neuropathy.This double-blind randomized clinical trial study was performed on 60 cancer patients treated with cisplatin chemotherapy at Seyyed-o-Shohada Hospital of Isfahan during 2019-2020. The patients were divided into two parallel groups as intervention (treated by SM) and placebo, and DN4 (Douleur neuropathique 4 questions) and CIPNAT (chemotherapy-induced peripheral neuropathy assessment tool) were completed for patients in the before and after intervention groups and compared between the two groups.The mean of DN4 score in the before and after study in the intervention group was in 1.76 ± 1.24 and 2.07 ± 2.03, respectively (P = 0.38), and in the control group was 1.41 ± 1.28 ± 3.11 ± 2.86, respectively (P = 0.012). The mean CIPNAT score in the intervention groups was 5.93 ± 3.65 and 4.20 ± 3.23 (P = 0.01), and in the control group was 4.20 ± 4.22 and 4.16 ± 4.03 (P = 0.39).Based on our data, SM is an effective agent in reducing peripheral neuropathy. The use of SM was associated with decreased scores of peripheral neuropathy and was helpful in patients undergoing chemotherapy with cisplatin.Copyright: © 2024 Advanced Biomedical Research.