胃食管反流病（GERD）是食管癌手术的常见并发症，会影响生活质量并增加食管狭窄和吻合口瘘的风险。温胆汤（WDD）是一种传统中草药配方，用于治疗各种胃肠道疾病，如胃炎、功能性消化不良和肠易激综合症。莫沙必利是一种促动力剂，作为选择性5-羟色胺4激动剂，增强胃肠动力。 评价WDD联合莫沙必利对食管癌术后GERD的治疗效果。 将80例GERD患者随机分为治疗组（接受WDD联合莫沙必利治疗）。与莫沙必利）和对照组（单独接受莫沙必利）组。该治疗于 2021 年 1 月至 2023 年 1 月进行。主要结果是使用反流病问卷 (RDQ) 测量的 GERD 症状得到改善。次要结果是改善食管动力（使用食管测压法测量）、胃排空（使用胃闪烁扫描术测量）和生活质量[通过 Short Form-36 (SF-36) 健康调查测量]。治疗组表现出显着的改善与对照组相比，RDQ 评分降低，食管运动参数改善，例如较低的食管括约肌压力、蠕动幅度和蠕动速度。与对照组相比，治疗组的胃排空率和 SF-36 评分（身体和精神领域）显着更高。两组均未观察到严重不良反应。WDD联合莫沙必利是食管癌术后GERD的有效且安全的治疗方法。它可以改善GERD症状、食管蠕动、胃排空和患者的生活质量。需要更大样本量和更长随访时间的进一步研究来证实这些发现。©作者2024。百事登出版集团有限公司出版。保留所有权利。

Gastroesophageal reflux disease (GERD) is a common complication of esophageal cancer surgery that can affect quality of life and increase the risk of esophageal stricture and anastomotic leakage. Wendan Decoction (WDD) is a traditional Chinese herbal formula used to treat various gastrointestinal disorders, such as gastritis, functional dyspepsia, and irritable bowel syndrome. Mosapride, a prokinetic agent, functions as a selective 5-hydroxytryptamine 4 agonist, enhancing gastrointestinal motility.To evaluate the therapeutic effects of WDD combined with mosapride on GERD after esophageal cancer surgery.Eighty patients with GERD were randomly divided into treatment (receiving WDD combined with mosapride) and control (receiving mosapride alone) groups. The treatment was conducted from January 2021 to January 2023. The primary outcome was improved GERD symptoms as measured using the reflux disease questionnaire (RDQ). The secondary outcomes were improved esophageal motility (measured using esophageal manometry), gastric emptying (measured using gastric scintigraphy), and quality of life [measured via the Short Form-36 (SF-36) Health Survey].The treatment group showed a notably reduced RDQ score and improved esophageal motility parameters, such as lower esophageal sphincter pressure, peristaltic amplitude, and peristaltic velocity compared to the control group. The treatment group showed significantly higher gastric emptying rates and SF-36 scores (in both physical and mental domains) compared to the control group. No serious adverse effects were observed in either group.WDD combined with mosapride is an effective and safe therapy for GERD after esophageal cancer surgery. It can improve GERD symptoms, esophageal motility, gastric emptying, and the quality of life of patients. Further studies with larger sample sizes and longer follow-up periods are required to confirm these findings.©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.