癌症对于患者或医疗保健管理者来说都是一个挑战。基于化疗或放疗或两者兼而有之的治疗方案会干扰患者的生活，使他遭受痛苦而不是得到缓解。这种负担促使科学家们寻找新的治疗方案，以减轻患者和医生的不便。植物提取物作为医疗替代品在癌症治疗中的益处已被证明。新的纳米制剂药物输送系统可能有助于克服治疗方案的障碍和障碍。本研究课题旨在评价两种植物提取物纳米乳液制剂对人黑色素瘤细胞系的抗癌作用。获得香芹酚和迷迭香精油，并配制纳米乳液。使用 TEM 表征 NE 的电荷和尺寸分布。培养并增殖A375人黑色素瘤细胞系，然后添加制备的NE的IC50。测试了细胞毒性、对血管生成和凋亡的影响。经过合成和表征，香芹酚纳米乳（CNE）和迷迭香纳米乳（RNE）均能够抑制黑色素瘤细胞系活力、血管生成，并增强 caspase- 的表达。 3 促凋亡标志物。迷迭香和香芹酚提取物纳米乳剂可能成为人类黑色素瘤治疗的新的革命性药物，并且这些制剂可以局部应用。

Cancer is a challenge for either the patient or the healthcare manager. Treatment protocols based on chemotherapy or radiotherapy, or both are interfering with the patient's life making him suffer rather than being alleviated. This burden pushed the scientists to search for new regimens that may help ameliorate patient as well as doctor inconvenience. Benefits of plant extracts as medical substitutes in cancer management have been proved. New nano formulated drug delivery systems may help overcoming remedy regimens barriers and obstacles. The present research topic aims to evaluate the anticancer power of two plant extracts in nano emulsion formulation on human melanoma cell line.Carvacrol and rosemary essential oils were obtained, and nano emulsions were formulated. NE were characterized using TEM for charge and size distribution. The A375 human melanoma cell line was cultured and propagated then IC50 of prepared NE was added. Assessment of cell cytotoxicity, effect on angiogenesis and apoptosis were tested.After synthesis and characterization, both carvacrol nano emulsion (CNE) and rosemary nano emulsion (RNE) were capable of inhibiting melanoma cell line viability, angiogenesis and they enhanced the expression of caspase-3 proapoptotic marker.Rosemary and carvacrol extract nano emulsions could be a new revolutionary agent in human melanoma therapy and these formulations can be applied locally.