放射引起的肺部疾病是胸部恶性肿瘤（包括乳腺癌）放疗后常见的一种潜在致命的剂量限制性毒性。旨在评估和比较 3D-CRT 和 IMRT 放疗治疗方式在乳腺癌女性患者中引起的早期肺部毒性生化、剂量测定和临床数据。本研究包括 15 名正常健康对照、15 名接受 IMRT 治疗的乳腺癌患者和 15 名接受 3D-CRT 治疗的乳腺癌患者。从对照组中获取一份血样，并从放疗前、放疗后和放疗 3 个月后的病例中抽取 3 份血样。IMRT 向乳腺肿瘤提供较高的辐射剂量，向作为危险器官的肺部提供较低的剂量。 IMRT和3D-CRT前血清IL-6水平与对照组水平相比无显着升高。与RT前相比，RT（IMRT和3DCRT）后血清IL-6水平显着升高。与放疗后立即的血清水平相比，放疗（IMRT 和 3D-CRT）3 个月后，IL-6 的血清水平没有显着下降。与对照组相比，RT（IMRT 和 3D-CRT）前血清 SP-D 水平没有显着升高。与RT前相比，RT（IMRT和3D-CRT）后血清SP-D水平显着升高。放疗（IMRT和3D-CRT）3个月后血清SP-D水平与放疗后即刻血清水平相比无显着下降。血清IL-6和SP-D水平可用于IMRT 可以诊断放疗引起的早期肺毒性，并且放射性肺炎的恢复率明显高于 3D-CRT。

Radiation-induced lung disease is a potentially fatal, dose-limiting toxicity commonly seen after radiotherapy of thoracic malignancies, including breast cancer.To evaluate and compare the early lung toxicity induced by 3D-CRT and IMRT radiotherapy treatment modalities in breast cancer female patients using biochemical, dosimetry and clinical data.this study included 15 normal healthy controls, 15 breast cancer patients treated with IMRT, and 15 breast cancer patients treated with 3D-CRT. One blood sample was obtained from the control group and 3 blood samples were withdrawn from cases before RT, after RT and after 3 months of RT.IMRT delivered higher radiation dose to the breast tumor and lower doses to the lung as an organ at risk. There was a non-significant increase in the serum levels of IL-6 before IMRT and 3D-CRT compared with its levels in the control group. There were significant increases in serum levels of IL-6 after RT (IMRT and 3DCRT) compared with its levels before RT. There was a non-significant decrease in the serum levels of IL-6 after 3 months of RT (IMRT and 3D-CRT) compared with its serum levels immediately after RT. There was a non-significant increase in the serum levels of SP-D before RT (IMRT and 3D-CRT) compared with its levels in the control group. There were significant-increases in serum levels of SP-D after RT (IMRT and 3D-CRT) compared with its levels before RT. There was a non-significant decrease in the serum levels of SP-D after 3 months of radiotherapy (IMRT and 3D-CRT) compared with its serum levels immediately after RT.serum of levels IL-6 and SP-D can be used to diagnose the occurrence of early lung toxicity due to radiotherapy and the rate of recovery from radiation pneumonitis is apparent in case of IMRT than 3D-CRT.