特级初榨橄榄油 (EVOO) 是地中海饮食的主食，富含酚类化合物，因其强大的生物活性作用而闻名，包括抗癌和抗炎特性。然而，它对血管健康的影响仍然相对未经探索。在这项研究中，我们研究了来自西班牙哈恩的“picual”特级初榨橄榄油提取物对内皮细胞的影响。蛋白质组学分析揭示了血管生成相关过程的调节。在随后的体外实验中，EVOO提取物抑制内皮细胞迁移、粘附、侵袭、ECM降解和管形成，同时诱导细胞凋亡。这些结果为提取物的抗血管生成潜力提供了有力的证据。我们的研究结果强调了 EVOO 提取物在减轻血管生成相关病变（如癌症、黄斑变性和糖尿病视网膜病变）方面的潜力。

Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects on vascular health remain relatively unexplored. In this study, we examined the impact of a "picual" EVOO extract from Jaén, Spain, on endothelial cells. Proteomic analysis revealed the modulation of angiogenesis-related processes. In subsequent in vitro experiments, the EVOO extract inhibited endothelial cell migration, adhesion, invasion, ECM degradation, and tube formation while inducing apoptosis. These results provide robust evidence of the extract's antiangiogenic potential. Our findings highlight the potential of EVOO extracts in mitigating angiogenesis-related pathologies, such as cancer, macular degeneration, and diabetic retinopathy.