本研究检查了 43 名接受造血干细胞移植 (HSCT) 的青春期前患者睾丸样本中的精原细胞数量。 HSCT 期间的高剂量化疗和/或放疗可能会影响需要保留生育能力的精子发生。结果显示，49% 的患者在 HSCT 前精原细胞库已减少，19% 严重耗尽。范可尼贫血患者的精原细胞数量显着减少。免疫缺陷或再生障碍性贫血患者的结果通常在正常范围内，而骨髓增生异常综合征或骨髓增生性肿瘤患者的结果则有所不同。该研究强调了评估严重血液疾病患者的精原细胞数量对于做出明智的生育力保存决策的重要性。© 2024 作者。英国血液学杂志由英国血液学会和约翰·威利出版

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.