Eph 受体构成最大的受体酪氨酸激酶家族，由 14 个不同的成员组成，分为两个亚组：EphAs 和 EphB。尽管它们在正常生理过程中发挥着重要作用，但越来越多的证据表明，Eph 家族参与癌症的特点是双重且常常矛盾的性质。研究表明 Eph/ephrin 双向信号传导影响细胞间通讯，从而调节细胞迁移、粘附、分化和增殖。 Eph信号通路的多样性和不同癌症微环境的异质性可能产生矛盾的功能。在这篇综述中，我们旨在讨论 Eph 受体在肿瘤发展中的双重作用，试图通过探索 Eph 受体信号通路、血管生成、免疫反应等来阐明其矛盾的功能。我们的目标是全面了解肿瘤发展的分子机制。此外，我们将探索利用 Eph 受体作为肿瘤治疗和诊断工具的潜在靶点的不断发展的前景。© 2024。作者。

Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiological processes, accumulating evidence suggests that the involvement of the Eph family in cancer is characterized by a dual and often contradictory nature. Research indicates that Eph/ephrin bidirectional signaling influences cell-cell communication, subsequently regulating cell migration, adhesion, differentiation and proliferation. The contradictory functionalities may arise from the diversity of Eph signaling pathways and the heterogeneity of different cancer microenvironment. In this review, we aim to discuss the dual role of the Eph receptors in tumor development, attempting to elucidate the paradoxical functionality through an exploration of Eph receptor signaling pathways, angiogenesis, immune responses, and more. Our objective is to provide a comprehensive understanding of the molecular mechanisms underlying tumor development. Additionally, we will explore the evolving landscape of utilizing Eph receptors as potential targets for tumor therapy and diagnostic tools.© 2024. The Author(s).