曲霉属物种的生物勘探。作为一个有前途的抗癌药物储存库:全面的文献计量调查。
Bioprospecting of Aspergillus sp. as a promising repository for anti-cancer agents: a comprehensive bibliometric investigation.
发表日期:2024
作者:
Himanshu Jangid, Sonu Garg, Piyush Kashyap, Arun Karnwal, Amrullah Shidiki, Gaurav Kumar
来源:
Frontiers in Microbiology
摘要:
据世界卫生组织称,癌症仍然是一个重大的全球健康挑战,到 2020 年将夺走近 1000 万人的生命。在寻求新的治疗方法的过程中,真菌,尤其是曲霉属物种,已成为具有良好抗癌特性的生物活性化合物的宝贵来源。本研究对 1982 年至今的出版物进行了全面的文献计量分析,绘制了曲霉菌在肿瘤学领域的研究概况。我们观察到,从 2000 年开始,研究活动显着增加,并从 2005 年起达到了显着的峰值。该分析确定了关键贡献者,包括 Mohamed GG(发表了 15 篇论文,被引用 322 次)和 El-Sayed Asa(发表了 14 篇论文,被引用 264 次)。该研究领域的领先国家包括印度、埃及和中国,其中以沙特国王大学和开罗大学为主导机构。确定的突出研究主题是“内生菌”、“绿色合成”、“抗菌”、“抗癌”和“生物活性”,表明药物开发正在向环境可持续的方向转变。我们的研究结果强调了曲霉在开发新的抗癌疗法方面的巨大潜力,并强调了进一步研究以利用这些天然化合物用于临床的必要性。版权所有 © 2024 Jangid、Garg、Kashyap、Karnwal、Shidiki 和 Kumar。
Cancer remains a significant global health challenge, claiming nearly 10 million lives in 2020 according to the World Health Organization. In the quest for novel treatments, fungi, especially Aspergillus species, have emerged as a valuable source of bioactive compounds with promising anticancer properties. This study conducts a comprehensive bibliometric analysis to map the research landscape of Aspergillus in oncology, examining publications from 1982 to the present. We observed a marked increase in research activity starting in 2000, with a notable peak from 2005 onwards. The analysis identifies key contributors, including Mohamed GG, who has authored 15 papers with 322 citations, and El-Sayed Asa, with 14 papers and 264 citations. Leading countries in this research field include India, Egypt, and China, with King Saud University and Cairo University as the leading institutions. Prominent research themes identified are "endophyte," "green synthesis," "antimicrobial," "anti-cancer," and "biological activities," indicating a shift towards environmentally sustainable drug development. Our findings highlight the considerable potential of Aspergillus for developing new anticancer therapies and underscore the necessity for further research to harness these natural compounds for clinical use.Copyright © 2024 Jangid, Garg, Kashyap, Karnwal, Shidiki and Kumar.