PHD（植物同源域）指蛋白成为癌症生物学中的中心表观遗传读取器和调节器，协调对肿瘤发生和肿瘤抑制至关重要的广泛细胞过程。这篇综述描述了 PHD 手指在癌症中的双重作用，强调了它们在染色质重塑、基因表达调控以及与细胞信号网络相互作用中的参与。 PHD Fingers 解释特定组蛋白修饰的能力强调了它们对基因表达模式的影响，影响关键的癌症相关过程，如细胞增殖、DNA 修复和细胞凋亡。该综述深入研究了某些 PHD 指蛋白的致癌潜力，例如 PHF1 和 PHF8，它们通过表观遗传失调和 Wnt 和 TGFβ 等信号通路的调节促进肿瘤进展。相反，它讨论了 PHD 指蛋白（例如 PHF2 和 ING 家族成员）的肿瘤抑制功能，这些蛋白通过与染色质和转录调节因子的相互作用维持基因组稳定性并抑制肿瘤生长。此外，考虑到 PHD 指蛋白在调节癌症干细胞和影响癌症治疗免疫反应方面的关键作用，该综述探讨了靶向 PHD 指蛋白在癌症治疗中的治疗潜力。通过对当前见解的全面综合，本综述强调了 PHD 指蛋白在癌症生物学中复杂但前景广阔的前景，提倡进一步研究以解锁利用其独特细胞作用的新治疗途径。版权所有 © 2024 Fan, Jiang, Zhou, Chi和曾。

PHD (plant homeodomain) finger proteins emerge as central epigenetic readers and modulators in cancer biology, orchestrating a broad spectrum of cellular processes pivotal to oncogenesis and tumor suppression. This review delineates the dualistic roles of PHD fingers in cancer, highlighting their involvement in chromatin remodeling, gene expression regulation, and interactions with cellular signaling networks. PHD fingers' ability to interpret specific histone modifications underscores their influence on gene expression patterns, impacting crucial cancer-related processes such as cell proliferation, DNA repair, and apoptosis. The review delves into the oncogenic potential of certain PHD finger proteins, exemplified by PHF1 and PHF8, which promote tumor progression through epigenetic dysregulation and modulation of signaling pathways like Wnt and TGFβ. Conversely, it discusses the tumor-suppressive functions of PHD finger proteins, such as PHF2 and members of the ING family, which uphold genomic stability and inhibit tumor growth through their interactions with chromatin and transcriptional regulators. Additionally, the review explores the therapeutic potential of targeting PHD finger proteins in cancer treatment, considering their pivotal roles in regulating cancer stem cells and influencing the immune response to cancer therapy. Through a comprehensive synthesis of current insights, this review underscores the complex but promising landscape of PHD finger proteins in cancer biology, advocating for further research to unlock novel therapeutic avenues that leverage their unique cellular roles.Copyright © 2024 Fan, Jiang, Zhou, Chi and Zeng.