本研究旨在确定术前成像中明显的胶质瘤边缘的存在是否与术中肿瘤-脑界面识别的改善以及非增强胶质瘤整体手术结果的改善相关。这是对我们机构所有原发性胶质瘤切除术的回顾性研究2000年至2020年之间。排除具有对比增强或具有除弥漫性浸润性神经胶质肿瘤（WHO II或WHO III）之外的最终病理学的肿瘤。肿瘤被分为两组：肿瘤和脑之间具有明显放射学边界的组，以及放射学边缘不明确的组。进行多变量分析以确定清晰的术前切缘对大体全切除主要结果的影响。在研究期间，59 名患者符合纳入标准，其中 31 名患者 (53%) 具有明显的切缘。这些患者主要年龄较年轻（37.6 岁 vs. 48.1 岁，P=0.007）。两个队列的肿瘤和其他患者特征相似，包括性别、偏侧性、大小、位置、肿瘤类型、分级和使用的手术辅助手段（P>0.05）。多变量回归发现，不同的术前切缘与总切除率的增加相关（P=0.02）。术前神经影像学的不同边缘也与外科医生对术中边缘的识别（P<0.0001）、研究期间较少的死亡（P=0.01）和较长的总生存期（P=0.03）呈正相关。术前成像与弥漫性神经胶质瘤手术切除的改善相关，因为不同的边缘可能与术中可区分的神经胶质瘤-大脑界面相关。进一步的前瞻性研究可能会发现这些发现的其他临床用途。

This study aimed to determine whether the presence of distinct glioma margins on preoperative imaging is correlated with improved intraoperative identification of tumor-brain interfaces and overall improved surgical outcomes of non-enhancing gliomas.This is a retrospective study of all primary glioma resections at our institution between 2000-2020. Tumors with contrast enhancement or with final pathology other than diffuse infiltrative glial neoplasm (WHO II or WHO III) were excluded. Tumors were stratified into two groups: those with distinct radiographical borders between tumor and brain, and those with ill-defined radiographical margins. Multivariate analysis was performed to determine the impact of clear preoperative margins on the primary outcome of gross-total resection.Within the study period, 59 patients met inclusion criteria, of which 31 (53%) had distinct margins. These patients were predominantly younger (37.6 vs. 48.1 years, P=0.007). Tumor and other patient characteristics were similar in both cohorts, including gender, laterality, size, location, tumor type, grade, and surgical adjuncts utilized (P>0.05). Multivariate regression identified that distinct preoperative margins correlated with increased rates of gross total resection (P=0.02). Distinct margins on preoperative neuroimaging also correlated positively with surgeon identification of intra-operative margins (P<0.0001), fewer deaths over the study period (P=0.01), and longer overall survival (P=0.03).Distinct glioma-parenchyma margins on preoperative imaging are associated with improved surgical resection for diffuse gliomas, as distinct margins may correlate with distinguishable glioma-brain interfaces intraoperatively. Further prospective studies may discover additional clinical uses for these findings.