肝外胆管癌（EBDC）是一种以肝外胆管癌和胆囊癌为主的复合恶性肿瘤。大多数EBDC患者确诊时已处于晚期，以远处转移为特征，肝脏是常见的转移部位之一。因此，本研究的目的是调查肝外胆管癌肝转移（EBDCLM）的临床病理特征，确定预后危险因素，并评估其长期预后。我们从SEER数据库中筛选出1922名符合条件的EBDCLM患者。Cox回归采用模型预测总生存期（OS）和癌症特异性生存期（CSS）的独立预后因素，并绘制Kaplan-Meier生存曲线。根据多变量Cox分析结果构建列线图，评估列线图的预测效果。年龄、手术、化疗、脑转移和肺转移是OS和CSS的常见独立预后因素，放疗和骨转移是影响OS和CSS的独立预后因素。是 CSS 的独立预后因素。 Kaplan-Meier 生存曲线显示，年龄小于或等于 70 岁、接受手术和化疗且无肺转移的患者的生存率显着增加。结果表明，我们构建的列线图具有良好的预测性，具有较强的临床应用价值。我们的研究确定年龄、手术、化疗、脑转移和肺转移是EBDCLM患者的独立预后因素。列线图可以准确预测生存概率，有助于临床医生评估晚期 EBDC 患者的预后并提供个性化的临床决策。版权所有 © 2024 作者。由 Wolters Kluwer Health, Inc. 出版

Extrahepatic bile duct cancer (EBDC) is a compound malignant tumor mainly consisting of extrahepatic cholangiocarcinoma and gallbladder carcinoma. Most EBDC patients are diagnosed at an advanced stage characterized by distant metastases, and the liver is one of the common sites of metastasis. Hence, the purpose of this study is to investigate the clinicopathological features, identify prognostic risk factors, and assess the long-term prognosis of extrahepatic bile duct cancer liver metastasis (EBDCLM).We identified 1922 eligible EBDCLM patients from the SEER database.Cox regression models were used to predict independent prognostic factors for overall survival (OS) and cancer-specific survival (CSS),and Kaplan-Meier survival curves were drawn. A nomogram was constructed based on the results of multivariate Cox analysis, and the predictive effect of the nomogram was evaluated.Age, surgery, chemotherapy, brain metastasis, and lung metastasis were common independent prognostic factors for OS and CSS, and radiotherapy and bone metastasis were independent prognostic factors for CSS. The Kaplan-Meier survival curves showed a significant increase in survival for patients aged less than or equal to 70 years, undergoing surgery and chemotherapy, and without lung metastases. The results showed that the nomogram constructed by us had good predictability and ha d strong clinical application value.Our study identified age, surgery, chemotherapy, brain metastasis, and lung metastasis as independent prognostic factors for EBDCLM patients. The nomogram can accurately predict the survival probability, which is helpful for clinicians to assess the prognosis of patients with advanced EBDC and provide personalized clinical decisions.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.