背景：槲寄生是一种生长在杜库植物（Lancium demosticum）上的草本植物，在印度尼西亚被称为 benalu duku (BD)。预计它具有抗癌或抗病毒特性等益处，并且还被认为具有抗糖尿病药理活性。槲皮素样化合物（QLC）是具有抗糖尿病活性的次级代谢产物，口服后有望降低动物的血糖水平。目的：本研究旨在以实验动物作为临床模型，分析 QLC 降低随机血糖水平的能力。材料和方法：采用的研究方法是探索性的，采用前后测试模型，对治疗后的随机血糖水平进行观察。从 BD 叶中提取次生代谢物，然后进行筛选。通过每天给予 0.045 mg/g 体重的链脲佐菌素连续 2 天，对 30 只大鼠（褐家鼠）诱发糖尿病。在糖尿病大鼠中测试了次生代谢物以 0.5 mg/kg 体重（每天两次）的剂量口服给药长达 5 天的抗糖尿病作用。使用 One Touch Ultra Plus 医疗设备测量随机血糖水平 (mg/dL)，以观察随机血糖水平。结果和新颖性：结果表明，二次代谢物作为 BD 叶提取物的分析物，可以显着降低随机血糖水平。结论：从BD中提取的次级代谢产物可用于治疗大鼠糖尿病。

Background: Mistletoe is an herb that grows on duku plants (Lancium demosticum) and is known as benalu duku (BD) in Indonesia. It is predicted to have benefits such as anticancer or antiviral properties, and it is also thought to have anti-diabetic pharmacological activity. Quercetin-like compounds (QLCs) are secondary metabolites with antidiabetic activity that are expected to lower blood sugar levels in animals after oral administration. Objective: This study aimed to analyze the ability of QLCs to reduce random blood sugar levels using experimental animals as clinical models. Material and methods: The research method used was exploratory, which used a before-after test model, and observations were made on the random blood sugar levels after treatment. Secondary metabolites were extracted from BD leaves, which were then screened. Diabetes was induced in 30 rats (Rattus norvegicus) by the administration of streptozotocin at 0.045 mg/g body weight daily for 2 days. The antidiabetic effects of the secondary metabolite at doses of 0.5 mg/kg body weight (twice a day) when administered orally for up to 5 days were tested in diabetic rats. The random sugar levels (mg/dL) were measured using a One Touch Ultra Plus medical device for observation of randomized blood sugar levels. Results and novelty: The results revealed that the secondary metabolite, as an analyte from the BD leaf extract, can significantly reduce random blood sugar levels. Conclusion: The secondary metabolite extracted from BD, could be used to treat diabetes in rats.