晚期上皮性卵巢癌（OC）患者常出现营养不良；然而，理想的营养评估工具尚不清楚。我们的目的是评估术前白蛋白、预后营养指数 [PNI]、中性粒细胞与淋巴细胞比率 [NLR] 和血小板与淋巴细胞比率 [PLR] 作为严重术后并发症和 90 天死亡率的独立预测因子的作用。接受初次肿瘤细胞减灭术以确定理想工具的 OC 患者。包括在梅奥诊所 (2003-2018) 接受手术的 OC 患者；回顾性检索生物标志物并利用既定的临界值。结果包括严重并发症（手风琴级别≥3）和 90 天死亡率。进行了单变量和多变量逻辑回归模型。在单独的模型中评估生物标志物，根据年龄和美国麻醉医师协会 (ASA) 评分调整 90 天死亡率，并根据年龄、ASA 评分、分期和手术复杂性调整严重并发症。白蛋白 <3.5 g/dL，PNI < 45、NLR > 6 和 PLR ≥ 200 与 627 名符合纳入标准的患者的 90 天死亡率单变量相关（所有 p < 0.05）。每个标志物在调整后的模型中仍然显着，其中白蛋白具有最高 OR：6.04 [95% CI：2.80-13.03] 和 AUC (0.83)。单变量方面，PNI <45、NLR >6 和 PLR ≥200 是严重并发症的显着预测因子（所有 p < 0.05），但在调整后的模型中未能达到显着性。白蛋白与严重并发症无关。在调整模型中，所有生物标志物均与 90 天死亡率相关，其中白蛋白是临床上最容易实现的预测因子；无一例出现严重并发症。未来的研究应少关注营养评估方法，而更多关注 OC 肿瘤定向治疗期间改善营养的策略。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Advanced epithelial ovarian cancer (OC) patients often present with malnutrition; however, the ideal nutritional evaluation tool is unclear. We aimed to evaluate the role of preoperative albumin, Prognostic Nutritional Index [PNI], neutrophil-to-lymphocyte ratio [NLR], and platelet-to-lymphocyte ratio [PLR] as independent predictors of severe postoperative complications and 90-day mortality in OC patients who underwent primary cytoreductive surgery to identify the ideal tool.OC patients who underwent surgery at Mayo Clinic (2003-2018) were included; biomarkers were retrospectively retrieved and established cut-offs were utilized. Outcomes included severe complications (Accordion grade ≥ 3) and 90-day mortality. Univariate and multivariable logistic regression models were performed. Biomarkers were evaluated in separate models adjusted for age and American Society of Anesthesiologists (ASA) score for 90-day mortality, and adjusted for age, ASA score, stage, and surgical complexity for severe complications.Albumin <3.5 g/dL, PNI < 45, NLR > 6 and PLR ≥ 200 were univariately associated with 90-day mortality (all p < 0.05) in 627 patients that met inclusion criteria. Each marker remained significant in adjusted models with albumin having the highest OR: 6.04 [95% CI:2.80-13.03] and AUC (0.83). Univariately, PNI <45, NLR >6, and PLR ≥200 were significant predictors of severe complications(all p < 0.05), however failed to reach significance in adjusted models. Albumin was not associated with severe complications.All biomarkers were associated with 90-day mortality in adjusted models, with albumin being the easiest predictor to attain clinically; none with severe complications. Future research should focus less on methods of nutritional assessment and more on strategies to improve nutrition during OC tumor-directed therapy.Copyright © 2024 Elsevier Inc. All rights reserved.