基于纳米技术的药物输送系统（包括 siRNA）提供了一种治疗乳腺癌的创新方法，乳腺癌对女性的影响尤为严重。这些系统可实现个性化和靶向治疗，擅长管理耐药性并最大限度地减少脱靶效应。这篇综述深入探讨了纳米技术衍生的 siRNA 转运系统用于乳腺癌治疗的现状，讨论了它们的作用机制、临床前和临床研究、治疗应用、挑战和未来前景。重点强调靶向递送和精确基因沉默对于提高治疗效果和患者结果的重要性。该审查解决了特异性、生物分布、免疫反应和监管审批等具体障碍，为未来的研究提供了潜在的解决方案和途径。 SiRNA 药物输送系统有望彻底改变癌症治疗和改善患者治疗效果，但要充分发挥其潜力，需要持续的研究、创新和合作。了解 siRNA 传递机制的复杂性对于设计有效的癌症治疗、克服挑战以及推进基于 siRNA 的各种疾病（包括癌症）疗法的关键。本文全面回顾了治疗应用中 siRNA 运输的方法，特别是在癌症治疗中，阐明了 siRNA 分子从细胞外空间到细胞内靶标的复杂旅程。探索了内吞作用、受体介导的摄取和膜融合等关键机制，以及提高 siRNA 递送效率的创新递送载体和技术。此外，文章还讨论了该领域的挑战和机遇，包括与特异性、生物分布、免疫反应和临床转化相关的问题。通过了解 siRNA 传递机制，研究人员可以针对包括癌症在内的各种疾病设计和开发更有效的基于 siRNA 的疗法。版权所有 © 2024。由 Elsevier B.V. 出版。

Nanotechnology-based drug delivery systems, including siRNA, present an innovative approach to treating breast cancer, which disproportionately affects women. These systems enable personalized and targeted therapies, adept at managing drug resistance and minimizing off-target effects. This review delves into the current landscape of nanotechnology-derived siRNA transport systems for breast cancer treatment, discussing their mechanisms of action, preclinical and clinical research, therapeutic applications, challenges, and future prospects. Emphasis is placed on the importance of targeted delivery and precise gene silencing in improving therapeutic efficacy and patient outcomes. The review addresses specific hurdles such as specificity, biodistribution, immunological reactions, and regulatory approval, offering potential solutions and avenues for future research. SiRNA drug delivery systems hold promise in revolutionizing cancer care and improving patient outcomes, but realizing their full potential necessitates ongoing research, innovation, and collaboration. Understanding the intricacies of siRNA delivery mechanisms is pivotal for designing effective cancer treatments, overcoming challenges, and advancing siRNA-based therapies for various diseases, including cancer. The article provides a comprehensive review of the methods involved in siRNA transport for therapeutic applications, particularly in cancer treatment, elucidating the complex journey of siRNA molecules from extracellular space to intracellular targets. Key mechanisms such as endocytosis, receptor-mediated uptake, and membrane fusion are explored, alongside innovative delivery vehicles and technologies that enhance siRNA delivery efficiency. Moreover, the article discusses challenges and opportunities in the field, including issues related to specificity, biodistribution, immune response, and clinical translation. By comprehending the mechanisms of siRNA delivery, researchers can design and develop more effective siRNA-based therapies for various diseases, including cancer.Copyright © 2024. Published by Elsevier B.V.