滤泡细胞起源的甲状腺癌存在组织病理学和临床谱。作者重点关注位于非常有利的分化良好的甲状腺癌和非常不利的未分化甲状腺癌之间的肿瘤类别。这些中等侵袭性肿瘤包括低分化甲状腺癌和新定义的分化高级别甲状腺癌。这两种诊断都需要满足某些组织病理学要求，以便在术后准确识别这些肿瘤。治疗仍以手术为主，但分子靶向治疗（例如酪氨酸激酶抑制剂）和分化治疗（以恢复肿瘤对放射性碘的反应）等辅助治疗也逐渐可用。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Thyroid carcinoma of follicular cell origin exists on a histopathologic and clinical spectrum. The authors focus on the category of tumors that fall between the very favorable well-differentiated thyroid carcinomas and the very unfavorable anaplastic thyroid carcinomas. These intermediately aggressive tumors include poorly differentiated thyroid carcinoma and the newly defined differentiated high-grade thyroid carcinoma. Both diagnoses require certain histopathologic requirements be met in order to accurately identify these tumors post-operatively. Management remains primarily surgical though adjunctive treatments such as molecular targeted therapies (eg, tyrosine kinase inhibitors) and differentiation therapy (to restore tumor response to radioactive iodine) are also becoming available.Copyright © 2024 Elsevier Inc. All rights reserved.