机器人辅助食管切除术和全中食管切除术增强了食管癌患者的 R0 切除:单中心经验。
Robotic-assisted esophagectomy with total mesoesophageal excision enhances R0-resection in patients with esophageal cancer: A single-center experience.
发表日期:2024 Jun 29
作者:
Jens P Hoelzen, Lukas Fortmann, Dhruvajyoti Roy, Carsten Szardenings, Martina Holstein, Ann-Kathrin Eichelmann, Emile Rijcken, Brooke E Frankauer, Peter Barth, Eva Wardelmann, Andreas Pascher, Mazen A Juratli
来源:
HEART & LUNG
摘要:
这项研究的重点是检查机器人辅助微创食管切除术的日益增长的使用。具体来说,它评估了将机器人辅助微创食管切除术与系统性全食管切除术相结合的直接临床和癌症相关结果,而不是采用结构化全食管切除方案的传统开放式经胸食管切除术。对 185 例机器人辅助微创食管切除术和 223 例标准化 Ivor Lewis 食管切除术后的开放性经胸食管切除术进行评分匹配分析。经过 1:1 最近邻匹配以解释协变量的混杂因素后,对 181 例机器人辅助微创食管切除术和 181 例开放式经胸食管切除术的结果进行了比较。患者特征在年龄分布和冠心病等合并症方面显示出显着差异。动脉高血压和抗凝剂的摄入。机器人辅助微创食管切除术的 R0 切除率 (96.7%) 显着高于开胸经胸食管切除术 (89.0%, P = .004)。三十天死亡率和住院死亡率没有显着差异。机器人辅助微创食管切除术术后肺炎发生率 (12.7%) 显着降低(开放式经胸食管切除术 28.7%,P < .001)。机器人辅助微创食管切除术的重症监护病房住院时间 (P < .001) 和住院时间 (P < .001) 显着缩短。 这项采用倾向评分匹配的单中心回顾性研究发现,结合机器人辅助微创食管切除术与开放性经胸食管切除术相比,采用结构化全中食管切除术的食管切除术具有更好的短期临床和肿瘤学结果。这一发现意义重大,因为 R0 切除率的增加可能表明长期生存改善的可能性更高。此外,增强术后整体恢复可能有助于更好地管理食管切除术的风险。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。
The focus of this research is to examine the growing use of robotic-assisted minimally invasive esophagectomy. Specifically, it evaluates the immediate clinical and cancer-related results of combining robotic-assisted minimally invasive esophagectomy with a systematic approach to total mesoesophageal excision, as opposed to traditional open transthoracic esophagectomy methods that do not employ a structured total mesoesophageal excision protocol.A propensity score-matched analysis of 185 robotic-assisted minimally invasive esophagectomies and 223 open transthoracic esophagectomies after standardized Ivor Lewis esophagectomy was performed. After 1:1 nearest neighbor matching to account for confounding by covariates, outcomes of 181 robotic-assisted minimally invasive esophagectomy and 181 open transthoracic esophagectomy were compared.The patient characteristics showed significant differences in the age distribution and in comorbidities such as coronary heart disease, arterial hypertension, and anticoagulant intake. The R0-resection rate of robotic-assisted minimally invasive esophagectomy (96.7%) was significantly higher than open transthoracic esophagectomy (89.0%, P = .004). Thirty-day mortality and hospital mortality showed no significant differences. Postoperative pneumonia rate after robotic-assisted minimally invasive esophagectomy (12.7%) was significantly reduced (open transthoracic esophagectomy 28.7%, P < .001). Robotic-assisted minimally invasive esophagectomy had a significantly shorter intensive care unit stay (P < .001) and shorter hospital stay (P < .001).This single-center, retrospective study employing propensity score matching found that combining robotic-assisted minimally invasive esophagectomy with structured total mesoesophageal excision results in better short-term clinical and oncologic outcomes than open transthoracic esophagectomy. This finding is significant because the increased rate of R0 resection could indicate a higher likelihood of improved long-term survival. Additionally, enhanced overall postoperative recovery may contribute to better risk management in esophagectomy procedures.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.