利用临床和放射学特征开发了恶性肿瘤风险计算模型。其目的是比较肺结节风险计算模型并评估其对土耳其人群的有效性和适用性。 2014年至2019年间，对351名因肺结节接受手术的患者进行了以下数据评估：年龄、性别、吸烟史、肺癌家族史、肺外恶性肿瘤和肉芽肿性疾病、结节直径、衰减特征、侧面、部位、毛刺、结节计数、肺气肿的存在、结节 PET/CT 中 FDG 的摄取以及明确的病理学数据。使用 Brock、Mayo 和 Herder 模型的方程计算恶性肿瘤风险评分。对结果进行统计评价。 351名患者（236名男性，115名女性）的平均年龄为57.84±10.87（范围14-79）岁，观察到226个恶性结节和125个良性结节。恶性肿瘤与年龄 (p < 0.001)、结节直径 (p < 0.001)、性别 (p < 0.009)、推测 (p < 0.001)、肺气肿 (p < 0.05)、FDG 摄取 (p < 0.001) 之间存在显着相关性。所有三种模型均在分化方面有效（p< 0.001）。理想阈值由 Brock (19.5%)、Mayo (23.1%) 和 Herder (56%) 模型确定。所有模型都对  > 10 毫米的结节有效，但没有一个模型对 0-10 毫米的结节有效。 Brock 对毛玻璃结节有效 (p = 0.02)，所有模型对半实性结节和实性结节均有效。没有一个组可以提供与原始研究中达到的 AUC 值一样高的值。这表明需要优化土耳其人口的模型和恶性肿瘤风险阈值。© 2024。作者。

Malignancy risk calculation models were developed using the clinical and radiological features. It was aimed to compare pulmonary nodule risk calculation models and evaluate their effectiveness and applicability for the Turkish population. Between 2014 and 2019, 351 patients who were operated on for pulmonary nodules were evaluated with the following data: age, gender, smoking history, family history of lung cancer, extrapulmonary malignancy and granulomatous disease, nodule diameter, attenuation character, side, localization, spiculation, nodule count, presence of pulmonary emphysema, FDG uptake in PET/CT of the nodule, and definitive pathology data. Malignancy risk scores were calculated using the equations of the Brock, Mayo, and Herder models. The results were evaluated statistically. The mean age of the 351 patients (236 men, 115 women) was 57.84 ± 10.87 (range 14-79) years, and 226 malignant and 125 benign nodules were observed. Significant correlations were found between malignancy and age (p < 0.001), nodule diameter (p < 0.001), gender (p < 0.009), speculation (p < 0.001), emphysema (p < 0.05), FDG uptake (p < 0.001). All three models were found effective in the differentiation (p < 0.001). The ideal threshold value was determined for the Brock (19.5%), Mayo (23.1%), and Herder (56%) models. All models were effective for nodules of > 10 mm, but none of them were for 0-10 mm. Brock was effective in ground-glass nodules (p = 0.02) and all models were effective for semi-solid and solid nodules. None of the groups could provide AUC values as high as those achieved in the original studies. This suggests the need to optimize models and malignancy risk thresholds for Turkish population.© 2024. The Author(s).