异常子宫出血（AUB）是所有年龄段妇科中最常见和最常见的主诉，尤其是围绝经期和绝经后女性。我国女性 AUB 的范围包括多种器质性病理学。本研究的目的是评估子宫内膜厚度作为 AUB 女性子宫内膜恶性肿瘤预测因子的作用。这项横断面描述性观察性研究是在孟加拉国迈门辛医学院医院妇产科的 122 名围绝经期女性（40-50 岁）和 87 名绝经后（>50 岁）年龄组患有 AUB 的女性中进行的2020年2月至2021年8月。对这些患者进行了详细的病史调查和细致的全身、全身和局部检查。所有研究参与者均进行了相关检查，例如经阴道超声检查（TVS），然后通过扩张和刮宫进行子宫内膜活检。大多数女性围绝经期年龄为 41-45 岁，绝经后年龄为 51-55 岁。围绝经期的平均±标准差为 45.8±4.1 年，绝经后为 56.3±6.4 年。未产、高血压（HTN）、糖尿病（DM）以及围绝经期和绝经后激素摄入等危险因素在发生子宫内膜恶性肿瘤方面具有统计学意义。在围绝经期和绝经后测量子宫内膜厚度。围绝经期和绝经后子宫内膜厚度（ET）的平均值±标准差分别为11.3±4.4mm和7.2±6.3mm，具有统计学意义（p<0.001）。 TVS 的敏感性、特异性、阳性预测值 (PPV)、阴性预测值 (NPV) 和准确性在围绝经期分别为 85.5%、67.4%、81.2%、73.8% 和 78.7%，在围绝经期为 85.9%、20%、89%、75%

Abnormal uterine bleeding (AUB) is the most common and frequent presenting complaint in Gynaecology in all age group especially in perimenopausal and postmenopausal women. The spectrum of AUB in women of our country includes a wide varieties of organic pathology. The objective of this study was to assess the role of endometrial thickness as a predictor of endometrial malignancy among the women presenting with AUB. This cross-sectional descriptive type of observational study was conducted among 122 women of perimenopausal (40-50 years) and 87 women of postmenopausal (>50 years) age group presenting with AUB in the Obstetrics and Gynaecology department of Mymensingh Medical College Hospital, Bangladesh from February 2020 to August 2021. These patients were subjected to a detailed history and meticulous general, systemic and local examination. The relevant investigations like Transvaginal Sonography (TVS) followed by endometrial biopsy by dilatation and curettage were done in all study participants. Most of the women were in the age group 41-45 years in perimenopause and 51-55 years in postmenopause. Mean±SD was 45.8±4.1 years in perimenopause and 56.3±6.4 years in postmenopause. There was statistical significance in developing endometrial malignancy regarding risk factors of nulliparity, Hypertention (HTN), Diabetes mellitus (DM) and hormone intake between perimenopause and postmenopause. Endometrial thickness was measured in perimenopause and postmenopause. Mean±SD of Endometrial thickness (ET) in perimenopause and postmenopause was 11.3±4.4mm and 7.2±6.3mm with statistical significance (p<0.001). Sensitivity, specificity, Positive predictive value (PPV), Negative predictive value (NPV) and accuracy of TVS were 85.5%, 67.4%, 81.2%, 73.8% and 78.7% in perimenopause and 85.9%, 20%, 89%, 75% & 83.9% in postmenopause. Cut off limit of ET in detection of endometrial malignancy was 18.5mm with sensitivity 74.8% and specificity 63.6% in perimenopause and 12.2mm with sensitivity 81.0% and specificity 65.8% in postmenopausal women. Women with AUB, endometrial malignancy should be suspected when endometrial thickness on TVS >18.5mm and >12.2mm in perimenopause and postmenopausal age group respectively. TVS has high sensitivity in detection of endometrial malignancy both in perimenopausal and postmenopausal women with AUB and TVS is a reliable, noninvasive method.