孟加拉国贾肖尔高血压患者代谢综合征的频率和危险因素与代谢综合征的关联。
Frequency and Risk Factors Association with Metabolic Syndrome among the Hypertensive Patients in Jashore, Bangladesh.
发表日期:2024 Jul
作者:
G K Acherjya, M Ali, K Tarafder, S R Deb, K K Dan, H N Sarker, M R Amin
来源:
DIABETES & METABOLISM
摘要:
代谢综合征(METS)在糖尿病、冠状动脉疾病和中风的发展中起着关键作用。由于本期数据缺乏,本研究旨在评估高血压患者中 METS 的频率和危险因素的关联。这项横断面研究采用非概率目的抽样方法,于2019年1月1日至2019年6月30日招募了667名年龄在20至70岁之间的合格高血压患者。已知有糖尿病、甲状腺、肾脏、心脏或肝脏病史的高血压患者疾病、库欣综合征或恶性肿瘤以及继发性肥胖原因、确诊怀孕、卧床不起、服用降脂药物或影响脂质和糖代谢的药物均被排除在研究之外。本研究的高血压患者(新发或既定高血压患者)中的 METS 是通过 NCEP-ATPIII(国家胆固醇教育计划 - 成人治疗小组 III)标准证明的,具有以下两个或多个点 [a) 腰围增加 ≥102cm男性和女性身高 ≥88cm,b) 高甘油三酯血症:≥150mg/dl,c) 高密度脂蛋白胆固醇 (HDL-C) 降低,男性 <40mg/dL (1.04mmol/L),男性 <50mg/dL (1.29mmol/ L) 女性,d) 高空腹血糖:110mg/dl]。 METS 的频率显着较高(69.9%,p<0.001),其中女性占显着优势(52.5%,p<0.001),其中研究人群的平均年龄为 48±11 岁。性别 (p<0.001)、教育程度 (p=0.041)、职业 (p<0.001)、体重指数 (BMI) (p<0.001) 和高血压状况 (p=0.002) 在 METS 的发展中显示出高度显着的作用。调整混杂因素后进行二元逻辑回归分析,女性比男性高 17 倍 [调整奇数比 (AOR) =16.96,95% CI=4.91-58.66,p<0.001)],肥胖比非肥胖高 4 倍-肥胖[BMI(肥胖AOR=4.24,95% CI=2.55-7.98,p<0.001)],高血压状态[确定的高血压是新发高血压的两倍(新发AOR=0.60,95% CI=0.037-0.97) , p=0.037)] 是 METS 的显着且独立的预测因子。 BMI(27.7±4.2,p<0.001)、高腰围(60.4%,p<0.001)、高甘油三酯血症和 HDL 降低(46.0%,p<0.001 和 51.3%,p<0.001)被发现具有 METS 的科目。总之,孟加拉国贾肖尔的高血压患者中 METS 发生率较高,且显着危险因素与女性性别、教育程度、职业、BMI 和高血压状况相关。因此,对高血压患者代谢成分进行全面评估可能会降低心血管疾病的过早发病率和死亡率。
Metabolic Syndrome (METS) plays a pivotal role in the development of diabetes mellitus, coronary artery diseases and stroke. Due to the scarcity of data in this issue, this study aims to assess the frequency and risk factors association of METS among the hypertensive patients. This cross-sectional study recruited 667 eligible hypertensive patients aged between 20 and 70 years using non-probability purposive sampling method conducted from 1st January 2019 to 30th June 2019. Hypertensive patients with the known history of diabetes, thyroid, renal, cardiac, or hepatic disease, Cushing syndrome or malignancy and secondary causes of obesity, confirmed pregnancy, bed ridden, taking lipid lowering drugs or drugs that affect lipid and glucose metabolism were excluded from the study. METS among the hypertensive patients (DE novo or established hypertensive patients) of this study was demonstrated by NCEP-ATPIII (National Cholesterol Education Program-Adult Treatment Panel III) criteria having two or more of the following points [a) increased waist circumference ≥102cm in men and ≥88cm in women, b) hypertriglyceridemia: ≥150mg/dl, c) reduced High density lipoprotein cholesterol (HDL-C) <40mg/dL (1.04mmol/L) in men and <50mg/dL (1.29mmol/L) in women, d) high fasting blood glucose: 110mg/dl]. Significantly high frequency (69.9%, p<0.001) of METS was found with a significant female preponderance (52.5%, p<0.001) where the mean age of the study population was 48±11 years. Sex (p<0.001), education (p=0.041), occupation (p<0.001), Body mass index (BMI) (p<0.001) and hypertensive status (p=0.002) showed a highly significant role in the development of METS. Following binary logistic regression analysis after adjusting for confounders, the female sex was 17 times higher than the male [Adjusted odd ratio (AOR) =16.96, 95% CI=4.91-58.66, p<0.001)], obesity 4 times higher than non-obese [BMI (obese AOR=4.24, 95% CI=2.55-7.98, p<0.001)], hypertensive status [established hypertension two times higher than de novo (de-novo AOR=0.60, 95% CI=0.037-0.97, p=0.037)] were significant and independent predictors of METS. Significantly high BMI (27.7±4.2 and p<0.001), high waist circumference (60.4%, p<0.001) and hyper tri-glyceridaemia and reduced HDL (46.0%, p<0.001 and 51.3%, p<0.001) were found in the subjects with METS. In conclusion, high frequency of METS among the hypertensive patients was found in Jashore, Bangladesh with significant risk factors related to female sex, education, occupation, BMI and hypertensive status. So, a holistic evaluation of metabolic components among the hypertensive patients may reduce premature cardiovascular morbidity and mortality.