多发性骨髓瘤 (MM) 是一种成熟 B 细胞系肿瘤，其特征是浆细胞异常克隆增殖和单克隆蛋白（M 蛋白）的存在。该研究旨在揭示多发性骨髓瘤患者的临床特征、实验室检查结果、东部肿瘤合作组 (ECOG) 的表现状态和骨骼调查。这项描述性横断面研究于 2019 年 1 月至 2020 年 7 月在孟加拉国达卡达卡医学院医院血液科进行，样本量为 81。在获得知情口头同意后，以病例记录表收集数据来自患者和/或其法定监护人。考虑了相关的道德问题和数据质量保证。使用 SPSS 25.0 版对数据进行分析，并根据数据性质以图表形式呈现频率、百分比、平均值和标准差。适当进行统计检验，显着性水平为 5.0%，以评估统计关联性。患者的平均年龄为58.9±12.0岁。男女比例为2:1。 35例（43.2%）患者为吸烟者，仅2例（2.5%）有血液系统恶性肿瘤家族史。骨痛（72.8%）是最常见的症状，而高血压（59.1%）、糖尿病（29.5%）、呼吸系统疾病（11.3%）和心脏病（11.4%）是常见的合并症。最常见的 ECOG 体能状态是 ECOG-1（48.1%）。第 1 小时平均血红蛋白 (Hb) 为 9.4±2.3gm/dl，平均红细胞沉降率 (ESR) 为 89.5±42.1 mm。平均血清肌酐水平为 2.0±1.85 mg/dl，42 例（34.2%）≥2.0mg/dl。 50份文献中，血清乳酸脱氢酶（LDH）升高18份（36.0%）。 10例（14.5%）平均血清钙水平为9.6±1.8mg/dl>11.0mg/dL。 37例（49.3%）血清白蛋白<3.5gm/dl，37例（57.8%）β2-微球蛋白>5.5mg/dl，国际分期系统（ISS）III期为59.4%，Bence Jones蛋白（BJP）为存在于 46.7% 的病例中。 75.0%存在溶解性病变，其中38例（74.5%）椎骨受累，18例（35.2%）肋骨受累，14例（27.5%）颅骨受累，3例（5.9%）骨骼受累分别是股骨、肱骨、胸骨和肩胛骨。平均浆细胞百分比为62.1±24.9%。免疫固定电泳 (IFE) 显示 IgG (72.7%)、IgA (18.2%)、游离轻链 (FLC) (9.1%)。 29.0% 的病例 FLC 比率≥100。血清肌酐与 Hb 浓度 (p<0.05)、血清肌酐水平与 ISS 分期 (p<0.05) 和血清钙水平 (p<0/05) 之间观察到显着的统计相关性，而 BJP 现状与水平之间的相关性不显着。血清肌酐水平（p>0.05）。骨痛、疲劳、发烧和神经功能障碍是常见的症状。贫血、肾功能损害和骨骼溶解事件是主要的身体发现。 ISS分期与血清肌酐水平有统计学相关性，而血清钙水平与血清​​肌酐和溶解性病变相关。

Multiple myeloma (MM), mature B-cell lineage neoplasm, is characterized by abnormal clonal proliferation of plasma cells and presence of monoclonal protein (M protein). The study was conducted to reveal presenting features, laboratory findings, Eastern Cooperative Oncology Group (ECOG) performance status and skeletal survey on patients with multiple myeloma. This descriptive, cross-sectional study was carried out in the Department of Haematology, Dhaka Medical College Hospital, Dhaka, Bangladesh from January 2019 to July 2020 with a sample size of 81. Data were collected in a case record form after obtaining informed verbal consent from patients and /or their legal guardians. Relevant ethical issues and data quality assurance were taken into consideration. Data were analyzed with SPSS, Version 25.0 with presentation in figures and tables with frequency, percentage, mean and standard deviation based on data nature. Statistical tests were carried out as appropriate with 5.0% level of significance for assessing statistical association. Mean age of the patients was 58.9±12.0 years. Male female ratio was 2:1. 35(43.2%) patients were smokers with only 2(2.5%) had family history of haematological malignancies. Bone pain (72.8%) was the most common presenting feature, while hypertension (59.1%), diabetes mellitus (29.5%), respiratory illness (11.3%) and cardiac disease (11.4%) were the common co-morbidities. Most common ECOG performance status was ECOG-1(48.1%). Mean haemoglobin (Hb) was 9.4±2.3gm/dl and mean erythrocyte sedimentation rate (ESR) was 89.5±42.1 mm in 1st hour. Mean serum creatinine level was 2.0±1.85 mg/dl and ≥2.0mg/dl in 42(34.2%). Among 50 documentation serum lactate dehydrogenase (LDH) was raised in 18(36.0%). Mean serum calcium level was 9.6±1.8mg/dl >11.0mg/dL in 10(14.5%) cases. Serum albumin <3.5gm/dl in 37(49.3%), β2-microglobulin >5.5mg/dl in 37(57.8%) cases, International staging system (ISS) stage III was in 59.4% and Bence Jones Protein (BJP) was present in 46.7% cases. Lytic lesions were present in 75.0%, In 38(74.5%) patients vertebrae were involved, while in 18(35.2%) ribs were involved, in 14(27.5%) patients skull was involved and in 3(5.9%) patients involved bones were femur, humerus, sternum and scapula. Mean plasma cells percentage was 62.1±24.9%. Immuno-Fixation Electrophoresis (IFE) revealed IgG (72.7%), IgA (18.2%), Free light chain (FLC) (9.1%). FLC ratio was ≥100 in 29.0% cases. Significant statistical association was observed between serum creatinine with Hb concentration (p<0.05), serum creatinine level with ISS staging (p<0.05) and serum calcium level (p<0/05), while insignificant association was revealed between BJP present status and serum creatinine level (p>0.05). Bone pain, fatigue, fever and neurological impairment were the common presenting features. Anaemia, renal impairment and skeletal lytic events were the prominent physical findings. ISS staging was statistically associated with serum creatinine level, while serum calcium level was associated with serum creatinine and lytic lesions.