根除幽门螺杆菌（H. pylori）后的早期胃癌（EGC）通常表现为淡红色凹陷性病变（RDL）；同样的特征也出现在根除后的良性胃中。我们比较了幽门螺杆菌根除后良性和肿瘤性 RDL 的临床病理和内镜特征。研究了幽门螺杆菌根除后的 228 个肿瘤性 RDL。根据组织学将所有病变分为肿瘤性RDL（分化癌或腺瘤，n = 114）和良性RDL（n = 114）。比较肿瘤组和良性组的临床和病理特征。还评估了使用白光（WL）内窥镜检查、使用靛蓝胭脂红染料的染色内窥镜检查（CE）和窄带成像放大内窥镜检查（ME-NBI）的内窥镜诊断率与病理诊断的关系。肿瘤性 RDL 的尺寸较大高于良性 RDL（p<0.01）。 WL 预测 RDL 病理类型的敏感性、特异性和准确性分别为 70.1%、52.6% 和 61.4%，CE 预测 RDL 病理类型的敏感性、特异性和准确性分别为 65.8%、63.1% 和 65.4%，而 ME-NBI 得分较高，分别为 88.6%、88.6% 、 99.1% 和 93.9% 的敏感性、特异性和准确性。 ME-NBI 对于良性 RDL 的准确率为 99.9% (113/114)，对于肿瘤性 RDL 的准确率为 89.4% (101/114)。使用 ME-NBI 未诊断的肿瘤性 RDL 与分化程度较高的肿瘤（如腺瘤和高分化腺癌 (tub1)）以及存在不明确的分界线相关。ME-NBI 可用于诊断幽门螺杆菌根除后的 RDL，而某些使用 ME-NBI 很难诊断肿瘤性病变。

Early gastric cancers (EGCs) after Helicobacter pylori (H. pylori) eradication often appear as reddish depressed lesions (RDLs); the same features are also appeared in benign stomachs after eradication. We compared clinic-pathological and endoscopic features of benign and neoplastic RDLs after H. pylori eradication.228 neoplastic RDLs after H. pylori eradication were studied. All lesions were divided into neoplastic RDLs (differentiated carcinoma or adenoma, n=114) and benign RDLs (n=114) according to the histology. Clinical and pathological characteristics were compared in neoplastic and benign groups. Endoscopic diagnostic yields using the white light (WL) endoscopy, chromoendoscopy (CE) using indigo carmine dye and the magnifying endoscopy with narrow-band imaging (ME-NBI) were also evaluated in relation to the pathological diagnosis.Size of neoplastic RDLs was larger than that of benign RDLs (p<0.01). Sensitivity, specificity and accuracy for predicting pathological types of RDLs was 70.1%, 52.6% and 61.4% for the WL, 65.8%, 63.1% and 65.4% for the CE, while the ME-NBI scored better with the 88.6%, 88.6%, 99.1% and 93.9% of sensitivity, specificity and accuracy. The accuracy of the ME-NBI was 99.9% (113/114) in the benign RDLs and 89.4% (101/114) for the neoplastic RDLs. Undiagnosed neoplastic RDLs using the ME-NBI were associated with more differentiated tumors such as adenoma and well-differentiated adenocarcinoma (tub1) and the presence of an unclear demarcation line.ME-NBI is useful to diagnose RDLs after H. pylori eradiation, while some of neoplastic lesions are difficult to diagnose using the ME-NBI.