研究动态
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临终大肠梗阻的结肠造口术:患者可以从姑息手术中获得什么?

A colostomy for large bowel obstruction at the end of life: What do patients gain from palliative surgery?

发表日期:2024 Jun 29
作者: Roni Nitecki Wilke, Maria D Iniesta, Bryan Fellman, Amir A Jazaeri, Larissa A Meyer, Nicole D Fleming, Kathleen M Schmeler, Jolyn S Taylor
来源: GYNECOLOGIC ONCOLOGY

摘要:

恶性大肠梗阻 (LBO) 是影响妇科癌症女性的常见并发症,也是紧急手术的指征。然而,预期寿命和随后的医疗保健利用情况尚不清楚。我们试图估计结肠造口术后的总生存期 (OS),并描述晚期妇科恶性肿瘤患者随后的医疗保健利用情况。我们对 2014 年 3 月至 2014 年 3 月至 2014 年 3 月期间在我们机构因 LBO 因姑息性目的而接受结肠造口术的晚期妇科癌症患者进行了回顾性分析。 2023 年 1 月。汇总统计数据用于描述研究人群的临床和人口特征。使用 Kaplan-Meier 方法估算 OS,并使用国家质量论坛发布的标准定义临终时的医疗保健利用率。总共包括 78 名患者。手术时的中位年龄为 61 岁(范围:34-83 岁),大多数患者患有复发性卵巢癌、输卵管癌或原发性腹膜癌(n = 51,65.4%),其次是宫颈癌(n = 16, 20.5%)和子宫癌(n = 10, 12.8%)。查尔森合并症指数中位数为 3,术后住院时间中位数为 5 天(范围:1-26)。所有患者的中位随访时间为 4.5 个月(范围:0.07-46.2),中位 OS 为 4.5 个月(95% CI:2.9-6.0),其中 12 名患者 (15.4%) 的 OS <30 天且21 (26.9%) 的 OS 小于 60 天。在生命的最后 30 天内,62.7% 的患者再次入院,53.0% 的患者在急诊科就诊,18.5% 的患者住进重症监护室。很大一部分患者在死亡后 60 天内死亡。手术,许多人在临终时有很高的医疗保健利用率。版权所有 © 2024。由 Elsevier Inc. 出版。
Malignant large bowel obstruction (LBO) is a frequent complication affecting women with gynecologic cancers and is an indication for emergent surgery. However, the life expectancy and subsequent medical care utilization are unknown. We sought to estimate overall survival (OS) following colostomy and describe subsequent healthcare utilization among patients with advanced gynecologic malignancies.We conducted a retrospective analysis of patients with advanced gynecologic cancers who underwent colostomy with palliative intent due to LBO at our institution between March 2014 and January 2023. Summary statistics were used to describe the clinical and demographic characteristics of the study population. OS was estimated using the Kaplan-Meier method, and we defined healthcare utilization at the end-of-life using criteria published by the National Quality Forum.A total of 78 patients were included. The median age at the time of surgery was 61 (range: 34-83), and most patients had recurrent ovarian, fallopian tube, or primary peritoneal cancer (n = 51, 65.4%), followed by cervical cancer (n = 16, 20.5%), and uterine cancer (n = 10, 12.8%). The median Charlson comorbidity index was 3 and median postoperative length of stay was five days (range: 1-26). The median follow-up for all patients was 4.5 months (range: 0.07-46.2), and the median OS was 4.5 months (95% CI: 2.9-6.0), including 12 patients (15.4%) with <30-day OS and 21 (26.9%) with <60-day OS. In the last 30 days of life, 62.7% of patients were re-admitted to the hospital, 53.0% were seen in the emergency department, and 18.5% were admitted to an intensive care unit.A significant proportion of patients died within 60 days of surgery, and many had high healthcare utilization at the end of life.Copyright © 2024. Published by Elsevier Inc.