PtdIns 及其磷酸化衍生物（磷酸肌醇）是所有真核细胞中细胞内信号传导主要途径的生化成分。这些脂质在独特的位置异构体中很少，并且在数量上是大量细胞脂质组中的次要物种。然而，磷酸肌醇调节着一系列极其多样化的生物过程。正是从这个角度来看，磷酸肌醇依赖性信号通路的扰动越来越被认为是许多人类疾病（包括癌症）的因果基础。尽管磷脂酰肌醇转移蛋白 (PITP) 不是酶，但这些蛋白是磷酸肌醇信号传导的生理学重要调节剂。因此，PITP 在整个真核王国中都是保守的。尽管 PITP 具有重要的生物学意义，但其研究仍然不足。在此，我们回顾了有关 PITP 生物学的最新信息，主要关注 PITP 功能的紊乱如何破坏关键信号/发育途径，以及如何与哺乳动物中越来越多的病理学相关。版权所有 © 2024。由 Elsevier B.V. 出版。

PtdIns and its phosphorylated derivatives, the phosphoinositides, are the biochemical components of a major pathway of intracellular signaling in all eukaryotic cells. These lipids are few in terms of cohort of unique positional isomers, and are quantitatively minor species of the bulk cellular lipidome. Nevertheless, phosphoinositides regulate an impressively diverse set of biological processes. It is from that perspective that perturbations in phosphoinositide-dependent signaling pathways are increasingly being recognized as causal foundations of many human diseases - including cancer. Although phosphatidylinositol transfer proteins (PITPs) are not enzymes, these proteins are physiologically significant regulators of phosphoinositide signaling. As such, PITPs are conserved throughout the eukaryotic kingdom. Their biological importance notwithstanding, PITPs remain understudied. Herein, we review current information regarding PITP biology primarily focusing on how derangements in PITP function disrupt key signaling/developmental pathways and are associated with a growing list of pathologies in mammals.Copyright © 2024. Published by Elsevier B.V.