从 Alpinia katsumadai 的种子中分离出五种未描述的单萜-查耳酮缀合物 (1-5)、一种未描述的二芳基庚烷类假设前体 (6)、两种未描述的二芳基庚烷类化合物 (7-8) 和十四种已知化合物 (9-22)。通过 HRESIMS、NMR、ECD 和 X 射线衍射数据的解释，阐明了它们的结构。对人类癌细胞系（HepG2、A549、SGC7901、SW480）的 MTT 测定表明，化合物 3-8、11 和 13 表现出广谱抗增殖活性，IC50 值范围为 3.59 至 21.78 μM。通过网络药理学预测 B 细胞淋巴瘤 2 是 sumadain C (11) 的靶点，并通过均相时间分辨荧光测定和分子对接进行验证。版权所有 © 2024。由 Elsevier Ltd 出版。

Five undescribed monoterpene-chalcone conjugates (1-5), one undescribed hypothetical precursor of diarylheptanoid (6), two undescribed diarylheptanoids (7-8), and fourteen known compounds (9-22) were isolated from the seeds of Alpinia katsumadai. Their structures were elucidated through the interpretation of HRESIMS, NMR, ECD, and X-ray diffraction data. MTT assays on human cancer cell lines (HepG2, A549, SGC7901, SW480) revealed that compounds 3-8, 11, and 13 exhibited broad-spectrum antiproliferative activities with IC50 values ranging from 3.59 to 21.78 μM. B cell lymphoma 2 was predicted as the target of sumadain C (11) by network pharmacology and verified by homogeneous time-resolved fluorescence assay and molecular docking.Copyright © 2024. Published by Elsevier Ltd.