O-羧甲基壳聚糖（O-CMC）是通过将葡萄糖胺单元中的羟基（-OH）官能团替换为羧甲基（-CH2COOH）取代基而产生的壳聚糖衍生物，有效解决了壳聚糖在水溶液中固有的溶解度问题。 O-CMC 因其溶解度增强、粘度升高、毒性最小和有利的生物相容性而引起了人们的广泛关注。此外，O-CMC 具有抗菌、抗真菌和抗氧化特性，使其成为伤口愈合、组织工程、抗肿瘤治疗、生物传感器和生物成像等各种生物医学用途的有前途的候选者。此外，O-CMC 非常适合纳米颗粒、水凝胶、薄膜、微胶囊和片剂的制造，为有效的药物输送系统提供了机会。本综述概述了 O-CMC 的独特特征，根据当前研究对进展和未来潜力进行了分析，检查了临床实施的重大障碍，并预见了其在生物医学领域持续的重大影响。版权所有 © 2024。由 Elsevier B.V. 出版。

O-carboxymethyl chitosan (O-CMC) is a chitosan derivative produced through the substitution of hydroxyl (-OH) functional groups in glucosamine units with carboxymethyl (-CH2COOH) substituents, effectively addressing the inherent solubility issues of chitosan in aqueous solutions. O-CMC has garnered significant interest due to its enhanced solubility, elevated viscosity, minimal toxicity, and advantageous biocompatibility properties. Furthermore, O-CMC demonstrates antibacterial, antifungal, and antioxidant characteristics, rendering it a promising candidate for various biomedical uses such as wound healing, tissue engineering, anti-tumor therapies, biosensors, and bioimaging. Additionally, O-CMC is well-suited for the fabrication of nanoparticles, hydrogels, films, microcapsules, and tablets, offering opportunities for effective drug delivery systems. This review outlines the distinctive features of O-CMC, offers analyses of advancements and future potential based on current research, examines significant obstacles for clinical implementation, and foresees its ongoing significant impacts in the realm of biomedicine.Copyright © 2024. Published by Elsevier B.V.