锌酞菁颗粒介导的纳米光热解的抗肿瘤作用。
Antitumor effect of nanophotothermolysis mediated by zinc phthalocyanine particles.
发表日期：2024 Jun 28
作者：
Olga A Bezborodova, Andrey A Pankratov, Boris Y Kogan, Elena R Nemtsova, Julia B Venediktova, Tatyana A Karmakova, Alexander V Butenin, Raisa K-G Feizulova, Varvara A Khokhlova, Ekaterina A Obraztsova, Andrey D Kaprin
来源：
Nanomedicine
摘要：
纳米光热解（NPhT）效应被认为是开发高选择性抗癌治疗方式的一种方法。在此，我们在小鼠皮下同基因肿瘤模型中评估了 NPhT 与静脉注射锌酞菁颗粒 (ZnPcPs) 的抗肿瘤功效。在患有 S37 肉瘤的小鼠中，研究了 ZnPcPs 的生物分布，并显示了 ZnPcPs 介导的 NPhT 的高抗肿瘤功效，包括对转移性病变的反应。形态学研究表明局部NPhT诱导的血管损伤在肿瘤生长和肿瘤扩散抑制中起主要作用。不同组织学来源的小鼠肿瘤对治疗的敏感性不同。结果证明了 ZnPcPs 介导的 NPhT 治疗表面肿瘤的潜力。版权所有 © 2024。由 Elsevier Inc. 出版。
Nanophotothermolysis (NPhT) effect is considered to be an approach for the development of highly selective modalities for anticancer treatment. Herein, we evaluated an antitumor efficacy of NPhT with intravenously injected zinc phthalocyanine particles (ZnPcPs) in murine subcutaneous syngeneic tumor models. In S37 sarcoma-bearing mice a biodistribution of ZnPcPs was studied and the high antitumor efficacy of ZnPcPs-mediated NPhT was shown, including a response of metastatic lesions. The morphological investigation showed the main role of a local NPhT-induced vascular damage in the tumor growth and tumor spread inhibition. Murine tumors of different histological origin were not equally sensitive to the treatment. The results demonstrate a potential of ZnPcPs-mediated NPhT for treatment of surface tumors.Copyright © 2024. Published by Elsevier Inc.