氨基酸是蛋白质的重要​​组成部分、细胞生存的重要能源以及支持肿瘤细胞抵抗生长的关键信号分子。在肿瘤细胞中，氨基酸代谢重编程的特点是氨基酸的摄取增强以及氨基酸的合成、分解和运输异常，导致肿瘤细胞的免疫逃避和恶性进展。本文综述了肿瘤细胞氨基酸代谢的改变及其对肿瘤微环境的影响，并对氨基酸代谢目前的临床应用进行了概述。针对氨基酸代谢的创新药物为精准和个性化癌症治疗带来了巨大希望。© 2024 Wiley periodicals LLC。

Amino acids are essential building blocks for proteins, crucial energy sources for cell survival, and key signaling molecules supporting the resistant growth of tumor cells. In tumor cells, amino acid metabolic reprogramming is characterized by the enhanced uptake of amino acids as well as their aberrant synthesis, breakdown, and transport, leading to immune evasion and malignant progression of tumor cells. This article reviews the altered amino acid metabolism in tumor cells and its impact on tumor microenvironment, and also provides an overview of the current clinical applications of amino acid metabolism. Innovative drugs targeting amino acid metabolism hold great promise for precision and personalized cancer therapy.© 2024 Wiley Periodicals LLC.