精准靶向肠道微生物组进行癌症免疫治疗。
Precision Targeting of the Gut Microbiome for Cancer Immunotherapy.
发表日期:2024 Jul 01
作者:
Pasquale Lombardi, David J Pinato
来源:
Cancer Discovery
摘要:
将肠道微生物状态从预后特征转变为治疗靶点是了解和逆转抗癌免疫疗法耐药性的关键目标。 Glitza 及其同事提出在抗生素预处理后使用 SER401 对肠道微生物组进行选择性操作,并强调了将微生物组操作应用于临床的多重挑战。参见 Glitza 等人的相关文章,第 17 页。 1161 (8).©2024 美国癌症研究协会。
Transforming gut microbial status from a prognostic trait to a therapeutic target is a key goal to understand and reverse resistance to anticancer immunotherapy. Glitza and colleagues propose selective manipulation of the gut microbiome with SER401 following antibiotic preconditioning and highlight multiple challenges in delivering microbiome manipulation to the clinic. See related article by Glitza et al., p. 1161 (8).©2024 American Association for Cancer Research.