神经炎症、有毒蛋白质聚集、氧化应激和线粒体功能障碍是阿尔茨海默病 (AD) 等神经退行性疾病的关键途径。使用抗氧化剂、抗炎化合物以及 Aβ 形成和聚集抑制剂来针对这些机制对于治疗至关重要。海藻是生物活性化合物的丰富来源，包括碳水化合物、酚类、脂肪酸、藻胆蛋白、类胡萝卜素、脂肪酸和维生素。近年来，它们因其卓越的生物活性（包括抗炎、抗氧化、抗癌和抗凋亡特性）而引起了制药和营养保健品行业的兴趣。多项证据揭示了这些多功能藻类化合物在治疗和管理 AD 方面的潜在神经保护作用。本文将基于神经炎症和 AD 的体外和体内模型，深入了解藻类生物活性化合物的神经保护作用的分子机制。我们还将讨论它们作为 AD 疾病缓解和对症治疗策略的潜力。版权所有 ©2024，耶鲁生物与医学杂志。

Neuroinflammation, toxic protein aggregation, oxidative stress, and mitochondrial dysfunction are key pathways in neurodegenerative diseases like Alzheimer's disease (AD). Targeting these mechanisms with antioxidants, anti-inflammatory compounds, and inhibitors of Aβ formation and aggregation is crucial for treatment. Marine algae are rich sources of bioactive compounds, including carbohydrates, phenolics, fatty acids, phycobiliproteins, carotenoids, fatty acids, and vitamins. In recent years, they have attracted interest from the pharmaceutical and nutraceutical industries due to their exceptional biological activities, which include anti-inflammation, antioxidant, anticancer, and anti-apoptosis properties. Multiple lines of evidence have unveiled the potential neuroprotective effects of these multifunctional algal compounds for application in treating and managing AD. This article will provide insight into the molecular mechanisms underlying the neuroprotective effects of bioactive compounds derived from algae based on in vitro and in vivo models of neuroinflammation and AD. We will also discuss their potential as disease-modifying and symptomatic treatment strategies for AD.Copyright ©2024, Yale Journal of Biology and Medicine.