上皮样血管内皮瘤是一种罕见的血管恶性肿瘤，目前该病尚无标准治疗方案，现有治疗方案疗效有限。在本病例报告中，我们介绍了一名患有前列腺上皮样血管内皮瘤肺和淋巴结转移的患者，该患者取得了显着的部分缓解。这是通过纳武单抗与伊匹单抗和脂质体阿霉素交替治疗来实现的，迄今为止，无进展生存期超过 6 个月。整个治疗过程耐受性良好。我们的报告表明，抗 PD-1 抗体加阿霉素交替的双重免疫疗法可能是上皮样血管内皮瘤的潜在治疗方式。然而，需要更大样本的研究来确定这种治疗策略的有效性，并且必须继续监测该患者以维持无进展生存期和总生存期。版权所有 © 2024 张，叶，杨，李，黄，周，冯、刘和谢。

Epithelioid hemangioendothelioma is a rare vascular malignancy, and currently, there is no standard treatment regimen for this disease and existing treatment options have limited efficacy. In this case report, we present a patient with lung and lymph node metastases from prostate epithelioid hemangioendothelioma who achieved a significant partial response. This was accomplished through alternating nivolumab therapy with ipilimumab and liposomal doxorubicin, resulting in a progression-free-survival more than 6 months to date. The treatment was well-tolerated throughout. Our report suggests that dual immunotherapy alternating with anti-PD-1antibody plus doxorubicin may be a potential treatment modality for epithelioid hemangioendothelioma. However, larger sample studies are necessary to ascertain the effectiveness of this treatment strategy and it is essential to continue monitoring this patient to sustain progression-free survival and overall survival.Copyright © 2024 Zhang, Ye, Yang, Li, Huang, Zhou, Feng, Liu and Xie.