细胞焦亡（一种程序性细胞死亡形式）与肿瘤免疫之间的相互作用代表了一个新兴的研究领域。焦亡在癌症中表现出双重作用：它既可以促进肿瘤的发展，也可以通过激活抑制肿瘤逃逸和促进细胞死亡的免疫反应来抵消肿瘤的发展。当前的肿瘤免疫治疗策略，特别是 CAR-T 细胞治疗和免疫检查点抑制剂 (ICIs)，以及某些中药化合物的潜力，凸显了焦亡与癌症免疫之间的复杂关系。随着研究对肿瘤治疗中焦亡机制的深入研究，其在增强肿瘤免疫反应中的应用成为一种新的研究途径。本综述旨在阐明焦亡的机制、其对肿瘤生物学的影响以及肿瘤免疫治疗研究的进展。从研究开始至2023年8月22日，在PubMed、Embase、CNKI和万方数据库上进行了全面的文献综述。检索使用了“细胞焦亡”、“癌症”、“肿瘤”、“机制”、“免疫”、“gasdermin”、“ICB”、“CAR-T”、“PD-1”、“PD-L1”、“草药”、“植物药”、“中药”、“中药”、 “免疫疗法”，由 AND/OR 连接，捕捉焦亡和肿瘤免疫治疗的最新发现。焦亡由复杂的机制控制，Gasdermin 家族发挥着关键作用。虽然肿瘤免疫治疗应用前景广阔，但焦亡对肿瘤免疫影响的研究仍在不断发展。值得注意的是，某些中药成分已被确定为潜在的焦亡诱导剂，值得进一步探索。这篇综述巩固了目前关于焦亡在肿瘤免疫治疗中作用的知识。它揭示了焦亡是免疫治疗领域的一个有益因素，表明利用焦亡来开发新型癌症治疗策略（包括涉及中药的策略）代表了肿瘤学的前瞻性方法。版权所有 © 2024 Yin, Song, Bian, Wang,邓、吕、王。

The interaction between pyroptosis-a form of programmed cell death-and tumor immunity represents a burgeoning field of interest. Pyroptosis exhibits a dual role in cancer: it can both promote tumor development and counteract it by activating immune responses that inhibit tumor evasion and encourage cell death. Current tumor immunotherapy strategies, notably CAR-T cell therapy and immune checkpoint inhibitors (ICIs), alongside the potential of certain traditional Chinese medicinal compounds, highlight the intricate relationship between pyroptosis and cancer immunity. As research delves deeper into pyroptosis mechanisms within tumor therapy, its application in enhancing tumor immune responses emerges as a novel research avenue.This review aims to elucidate the mechanisms underlying pyroptosis, its impact on tumor biology, and the advancements in tumor immunotherapy research.A comprehensive literature review was conducted across PubMed, Embase, CNKI, and Wanfang Database from the inception of the study until August 22, 2023. The search employed keywords such as "pyroptosis", "cancer", "tumor", "mechanism", "immunity", "gasdermin", "ICB", "CAR-T", "PD-1", "PD-L1", "herbal medicine", "botanical medicine", "Chinese medicine", "traditional Chinese medicine", "immunotherapy", linked by AND/OR, to capture the latest findings in pyroptosis and tumor immunotherapy.Pyroptosis is governed by a complex mechanism, with the Gasdermin family playing a pivotal role. While promising for tumor immunotherapy application, research into pyroptosis's effect on tumor immunity is still evolving. Notably, certain traditional Chinese medicine ingredients have been identified as potential pyroptosis inducers, meriting further exploration.This review consolidates current knowledge on pyroptosis's role in tumor immunotherapy. It reveals pyroptosis as a beneficial factor in the immunotherapeutic landscape, suggesting that leveraging pyroptosis for developing novel cancer treatment strategies, including those involving traditional Chinese medicine, represents a forward-looking approach in oncology.Copyright © 2024 Yin, Song, Bian, Wang, Deng, Lv and Wang.