组蛋白脱乙酰酶 6 (HDAC6) 属于一类表观遗传靶标，已被发现是肿瘤与心血管疾病之间关联的关键蛋白。最近的研究集中在HDAC6在调节动脉粥样硬化、心肌梗死、心肌肥大、心肌纤维化、高血压、肺动脉高压和心律失常等心血管疾病中的关键作用。在此，我们综述HDAC6与心血管疾病的关联、HDAC6抑制剂在心血管疾病治疗中的研究进展，并讨论HDAC6抑制剂与其他治疗药物联合治疗心血管疾病的可行性。© 2024 The Authors.约翰·威利 (John Wiley) 出版的《癌症创新》

Histone deacetylase 6 (HDAC6) belongs to a class of epigenetic targets that have been found to be a key protein in the association between tumors and cardiovascular disease. Recent studies have focused on the crucial role of HDAC6 in regulating cardiovascular diseases such as atherosclerosis, myocardial infarction, myocardial hypertrophy, myocardial fibrosis, hypertension, pulmonary hypertension, and arrhythmia. Here, we review the association between HDAC6 and cardiovascular disease, the research progress of HDAC6 inhibitors in the treatment of cardiovascular disease, and discuss the feasibility of combining HDAC6 inhibitors with other therapeutic agents to treat cardiovascular disease.© 2024 The Authors. Cancer Innovation published by John Wiley & Sons Ltd. on behalf of Tsinghua University Press.