胶质瘤是脑部最常见的原发性恶性肿瘤，具有致残率高、复发率高的特点。尽管低级别胶质瘤（LGG）具有相对良性的生物学行为，但LGG患者的预后仍然存在很大差异。神经胶质瘤干细胞（GSC）被认为是神经胶质瘤细胞增殖、侵袭和治疗耐药的罪魁祸首。我们的研究基于 mDNAsi 和 WCGNA 筛选了一系列胶质瘤干细胞相关基因（GSCRG），最终通过 10 种机器学习方法的 101 种组合建立了可靠的单基因预后模型。我们的结果表明TNFAIP6的表达水平与LGG患者的预后呈负相关，这可能是促癌信号通路激活和免疫抑制的结果。总的来说，这项研究表明 TNFAIP6 是 LGG 中一个强有力且有价值的预后因素，并且可能成为 LGG 治疗的新靶标。© 2024 由 Elsevier Ltd 出版。

Glioma is the most common primary malignant tumor in the brain, characterizing by high disability rate and high recurrence rate. Although low-grade glioma (LGG) has a relative benign biological behavior, the prognosis of LGG patients still varies greatly. Glioma stem cells (GSCs) are considered as the chief offenders of glioma cell proliferation, invasion and resistance to therapies. Our study screened a series of glioma stem cell-related genes (GSCRG) based on mDNAsi and WCGNA, and finally established a reliable single-gene prognostic model through 101 combinations of 10 machine learning methods. Our result suggested that the expression level of TNFAIP6 is negatively correlated with the prognosis of LGG patients, which may be the result of pro-cancer signaling pathways activation and immunosuppression. In general, this study revealed that TNFAIP6 is a robust and valuable prognostic factor in LGG, and may be a new target for LGG treatment.© 2024 Published by Elsevier Ltd.