低级别胶质瘤（LGG）是一种普遍且致命的原发性脑恶性肿瘤，大多数患者会复发和进展。信号转导子和转录激活子（STAT）家族长期以来一直与肿瘤的发生和进展有关。然而，对 LGG 中 STAT 基因的表达状态和整体功能的综合评估仍然很大程度上没有报道。在本研究中，我们研究了 STAT 家族基因的表达与 LGG 进展之间的关联。通过结合生物信息学筛选和验证分析的综合分析，我们确定STAT1、STAT3和STAT5A上调并促进LGG的恶性进展。值得注意的是，我们的研究结果表明 STAT3 是调节 LGG 进展的关键预后标志物。 STAT3 成为控制 LGG 进展的最重要的预后指标。此外，我们对 STAT3 结合蛋白和差异表达相关基因 (DEG) 的调查表明，STAT3 通过刺激 STAT1、FOXO1 和 MYC 的表达，在 LGG 的进展中发挥着关键作用。总之，我们最近的研究对 STAT 家族基因进行了彻底分析，结果表明针对 STAT3 的治疗干预有可能成为治疗 LGG 患者的可行策略。版权所有 © 2024 Li、Jiang、Zhu、Jia 和 Li。

Low-grade glioma (LGG) is a prevalent and lethal primary brain malignancy, with most patients succumbing to recurrence and progression. The signal transducer and activator of transcription (STAT) family has long been implicated in tumor initiation and progression. However, a comprehensive evaluation of the expression status and overall function of STAT genes in LGG remains largely unreported. In this study, we investigated the association between the expression of STAT family genes and the progression of LGG. Through a comprehensive analysis that combined bioinformatics screening and validation assays, we determined that STAT1, STAT3, and STAT5A were upregulated and contributed to the malignant progression of LGG. Notably, our findings suggest that STAT3 is a critical prognostic marker that regulates the progression of LGG. STAT3 emerged as the most significant prognostic indicator governing the advancement of LGG. Additionally, our inquiry into the STAT3-binding proteins and differentially expressed-correlated genes (DEGs) revealed that STAT3 played a pivotal role in the progression of LGG by stimulating the expression of STAT1, FOXO1, and MYC. In summary, our recent study conducted a thorough analysis of the STAT family genes and revealed that directing therapeutic interventions towards STAT3 holds potential as a viable strategy for treating patients with LGG.Copyright © 2024 Li, Jiang, Zhu, Jia and Li.