评估了红罗非鱼（Oreochromis spp.）内脏水解产物（RTVH）的抗氧化和抗增殖活性。为此，将水解产物应用于三种癌细胞系（HepG2、Huh7 和 SW480）和对照细胞系（CCD-18Co）。最后，对水解产物影响最大的细胞系 (SW480) 和对照细胞系 (CCD-18Co) 进行 ApoTox-Glo Triplex 检测，以确定细胞凋亡、毒性和细胞活力。结果表明，与对照细胞相比，水解产物对三种癌细胞系具有选择性的剂量依赖性细胞毒作用。 RTVH的抗氧化能力与其对所评估的癌细胞的抗增殖能力之间存在关系，通过RTVH的作用，HepG2、Huh7和SW480的细胞存活率分别为34.68%、41.58%和25.41%。 RTVH 对癌细胞系 SW480 的作用不是由于诱导细胞凋亡，而是由于细胞膜破裂。© 2024 作者。由 Elsevier B.V. 出版

The antioxidant and antiproliferative activity of red tilapia (Oreochromis spp.) viscera hydrolysates (RTVH) was evaluated. For that, the hydrolysates was applied to three cancer cell lines (HepG2, Huh7 and SW480) and the control (CCD-18Co). Finally, the line on which the hydrolysate had the greatest effect (SW480) and the control (CCD-18Co) were subjected to the ApoTox-Glo Triplex Assay to determine apoptosis, toxicity, and cell viability. The result showed that hydrolysate had a dose-dependent cytotoxic effect selective on the three cancer cell lines, compared to the control cells. There is a relationship between the antioxidant capacity of RTVHs and their antiproliferative capacity on cancer cells evaluated, which achieved cell viability by action of RTVH of 34.68 and 41.58 and 25.41 %, to HepG2, Huh7 and SW480, respectively. The action of RTVH on cancer cell line SW480 is not due to the induction of apoptosis but to the rupture of the cell membrane.© 2024 The Authors. Published by Elsevier B.V.