精准治疗因其靶点最佳药物浓度、提高治疗效果、减少不良反应而成为首选。在过去的几年中，可喷雾或可注射的热敏水凝胶表现出了很高的治疗潜力。通过在室温下简单地与自由流动​​的溶胶相混合，可以将它们用作细胞生长支架或药物释放储库。受其独特性质的启发，热敏水凝胶已广泛应用于精准医学的药物输送和治疗平台。在这篇综述中，研究了用于精准治疗的热敏水凝胶的最新进展，涵盖从热凝胶机制和主要成分到生物医学应用，包括伤口愈合、抗肿瘤活性、成骨和牙周病、鼻窦和眼科疾病。还根据其独特的特点讨论了温敏水凝胶在精准治疗中最有前景的应用和趋势。© 2024 沉阳药科大学。由 Elsevier B.V. 出版

Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over the past few years, sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic potential. These can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room temperature. Inspired by their unique properties, thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision medicine. In this review, the state-of-the-art developments in thermosensitive hydrogels for precision therapy are investigated, which covers from the thermo-gelling mechanisms and main components to biomedical applications, including wound healing, anti-tumor activity, osteogenesis, and periodontal, sinonasal and ophthalmic diseases. The most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.© 2024 Shenyang Pharmaceutical University. Published by Elsevier B.V.