神经系统疾病的治疗在很大程度上依赖于神经治疗药物，但人们对其可能对生殖健康可能产生的负面影响存在值得注意的担忧。传统的临床前模型通常无法准确预测生殖毒性，这凸显了对更多生理相关系统的需求。类器官模型代表了一种同时研究神经毒性和生殖毒性的有前途的方法，为神经治疗药物和生殖系统之间复杂的相互作用提供了见解。在此，我们研究了神经治疗药物引起的生殖毒性的分子机制，并讨论了案例研究的实验结果。此外，我们还探讨了类器官模型在阐明神经药物暴露的生殖并发症方面的效用。讨论了类器官模型的原理，强调了它们在受控环境中重现神经发育过程和模拟药物引起的毒性的能力。解决了该领域的挑战和未来前景，重点是推进类器官技术，以改善生殖毒性评估和加强药物安全筛选。这篇综述强调了类器官模型在阐明神经治疗药物与生殖健康之间复杂关系方面的重要性。版权所有 © 2024 Abady、Jeong、Kwon、Assiri、Cho 和 Saadeldin。

The management of neurological disorders heavily relies on neurotherapeutic drugs, but notable concerns exist regarding their possible negative effects on reproductive health. Traditional preclinical models often fail to accurately predict reprotoxicity, highlighting the need for more physiologically relevant systems. Organoid models represent a promising approach for concurrently studying neurotoxicity and reprotoxicity, providing insights into the complex interplay between neurotherapeutic drugs and reproductive systems. Herein, we have examined the molecular mechanisms underlying neurotherapeutic drug-induced reprotoxicity and discussed experimental findings from case studies. Additionally, we explore the utility of organoid models in elucidating the reproductive complications of neurodrug exposure. Have discussed the principles of organoid models, highlighting their ability to recapitulate neurodevelopmental processes and simulate drug-induced toxicity in a controlled environment. Challenges and future perspectives in the field have been addressed with a focus on advancing organoid technologies to improve reprotoxicity assessment and enhance drug safety screening. This review underscores the importance of organoid models in unraveling the complex relationship between neurotherapeutic drugs and reproductive health.Copyright © 2024 Abady, Jeong, Kwon, Assiri, Cho and Saadeldin.