甲状腺髓样癌（MTC）是一种具有挑战性的恶性肿瘤。基于 AJCC 分期系统的 MTC 生存结果并不能在早期阶段中提供判别分类器。从监测、流行病学和最终结果 (SEER) 数据库中识别出 2000 年至 2018 年的 3601 名 MTC 患者。应用平滑曲线拟合、Cox比例风险回归和竞争风险分析。检测到年龄和log RR（总体死亡相对风险）之间的线性相关性。代表 45-50 岁、50-55 岁和 55-60 岁患者的 K-M 曲线之间观察到重叠。该研究队列被分为 3 个亚组，其中 2 个年龄界限设定为 45 岁和 60 岁。年龄界限每进一步提高，MTC 特异性死亡风险就会增加约“5%”，非死亡风险也会增加约“3 倍”。 MTC 特定的死亡风险。MTC 年龄截止点 45 岁和 60 岁之间的生存结果差异已得到明确定义。版权所有 © 2024 张、王、魏、李、朱和陈。

Medullary thyroid cancer (MTC) is a challenging malignancy. The survival outcome of MTC based on AJCC staging system does not render a discriminant classifier among early stages.3601 MTC patients from 2000 to 2018 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Smooth curve fitting, Cox proportional hazard regression and competing risk analysis were applied.A linear correlation between age and log RR (relative risk of overall death) was detected. Overlaps were observed between K-M curves representing patients aged 45-50, 50-55, and 55-60. The study cohort was divided into 3 subgroups with 2 age cutoffs set at 45 and 60. Each further advanced age cutoff population resulted in a roughly "5%" increase in MTC-specific death risks and an approximately "3 times" increase in non-MTC-specific death risks.The survival outcome disparity across age cutoffs at 45 and 60 for MTC has been well defined.Copyright © 2024 Zhang, Wang, Wei, Li, Zhu and Chen.