实体瘤疗效评估标准（RECIST）1.1是评估恶性肿瘤和淋巴结转移的临床和研究标准。然而，淋巴结状态的定量分析仅限于短轴直径（SAD）的测量，并且SAD中10毫米以下的转移淋巴结往往无法检测到。本研究的目的是评估多频磁共振弹性成像 (MRE) 添加到 RECIST 1.1 中检测淋巴结转移的价值。使用断层弹性成像技术，通过 1.5 T 的多频 MRE 前瞻性检查了 25 个良性淋巴结和 82 个转移性淋巴结后处理频率为 30、40、50 和 60 Hz（总扫描时间为 4 分钟）。作为软组织刚度替代值的剪切波速度以米/秒为单位。使用正电子发射断层扫描-计算机断层扫描作为鉴定经组织学证实的原发肿瘤的腹部淋巴结转移的参考标准。根据RECIST 1.1比较MRE与SAD的诊断性能，并使用广义线性混合模型和二元Logistic混合模型通过受试者工作特征曲线分析进行评估。计算不同截断值的敏感性、特异性和预测值。转移性淋巴结 (1.90 ± 0.57 m/s) 比良性淋巴结 (0.98 ± 0.20 m/s, P < 0.001) 更硬。计算得出截止速度为 1.32 m/s 时曲线下面积为 0.95。使用特异性为 1.0 的保守方法，我们发现敏感性（SAD/MRE/MRE SAD，0.56/0.84/0.88）、阴性预测值（0.41/0.66/0.71）和总体准确性（0.66/0.88/0.91）得到改善使用 MRE，甚至更高的 MRE 和 SAD 组合。基于更高的组织硬度，多频 MRE 将转移性腹部淋巴结检出率提高了 25%，即使对于 SAD ≤ 10 mm 的淋巴结也是如此。刚度信息可以快速获取，并且将成为 RECIST 的一个很有前景的补充。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 is a clinical and research standard for evaluating malignant tumors and lymph node metastasis. However, quantitative analysis of nodal status is limited to measurement of short axis diameter (SAD), and metastatic lymph nodes below 10 mm in SAD are often not detected. The purpose of this study was to evaluate the value of multifrequency magnetic resonance elastography (MRE) when added to RECIST 1.1 for detection of lymph node metastasis.Twenty-five benign and 82 metastatic lymph nodes were prospectively examined by multifrequency MRE at 1.5 T using tomoelastography postprocessing at 30, 40, 50, and 60 Hz (total scan time of 4 minutes). Shear wave speed as a surrogate of soft tissue stiffness was provided in m/s. Positron emission tomography-computed tomography was used as reference standard for identification of abdominal lymph node metastasis from histologically confirmed primary tumors. The diagnostic performance of MRE was compared with that of SAD according to RECIST 1.1 and evaluated by receiver operating characteristic curve analysis using generalized linear mixed models and binary logistic mixed models. Sensitivity, specificity, and predictive values were calculated for different cutoffs.Metastatic lymph nodes (1.90 ± 0.57 m/s) were stiffer than benign lymph nodes (0.98 ± 0.20 m/s, P < 0.001). An area under the curve of 0.95 for a cutoff of 1.32 m/s was calculated. Using a conservative approach with 1.0 specificity, we found sensitivity (SAD/MRE/MRE + SAD, 0.56/0.84/0.88), negative predictive values (0.41/0.66/0.71), and overall accuracy (0.66/0.88/0.91) to be improved using MRE and even higher for combined MRE and SAD.Multifrequency MRE improves metastatic abdominal lymph node detection by 25% based on higher tissue stiffness-even for lymph nodes with an SAD ≤10 mm. Stiffness information is quick to obtain and would be a promising supplement to RECIST.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.