癌症转移是癌症患者死亡的主要原因。在癌症转移中，癌细胞从原发肿瘤脱落，穿透附近的血管，并附着并渗出血管，在远处器官形成继发性肿瘤。这使得外渗成为转移级联的关键步骤。本文重点关注三阴性乳腺癌，综述了预期继发性肿瘤微环境的机械特性在循环肿瘤细胞外渗中所起的作用。具体来说，检查了物理调节的血管内皮糖萼屏障元件、血管流动因子和内皮下细胞外基质机械特性对癌细胞外渗的影响。本综述的最终目标是阐明驱动三阴性乳腺癌外渗的物理机制，因为这些机制可能是抗转移治疗的潜在新靶标。© 2024 作者。 FASEB 期刊由 Wiley periodicals LLC 代表美国实验生物学学会联合会出版。

Cancer metastasis is the leading cause of death for those afflicted with cancer. In cancer metastasis, the cancer cells break off from the primary tumor, penetrate nearby blood vessels, and attach and extravasate out of the vessels to form secondary tumors at distant organs. This makes extravasation a critical step of the metastatic cascade. Herein, with a focus on triple-negative breast cancer, the role that the prospective secondary tumor microenvironment's mechanical properties play in circulating tumor cells' extravasation is reviewed. Specifically, the effects of the physically regulated vascular endothelial glycocalyx barrier element, vascular flow factors, and subendothelial extracellular matrix mechanical properties on cancer cell extravasation are examined. The ultimate goal of this review is to clarify the physical mechanisms that drive triple-negative breast cancer extravasation, as these mechanisms may be potential new targets for anti-metastasis therapy.© 2024 The Author(s). The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.