设计并合成了一种基于环金属化Ir(III)配合物IrL的新型溶酶体靶向光敏剂/光氧化还原催化剂，该催化剂表现出优异的磷光性能以及产生单氧（1O2）和光催化氧化1,4-二氢烟酰胺腺嘌呤二核苷酸的能力（ NADH）在光照射下。最重要的是，由于酸性条件下的质子化，上述活性显着增强，这使得它们在光激活肿瘤治疗中极具吸引力，特别是对于酸性溶酶体和肿瘤微环境。 IrL 的光细胞毒性和细胞死亡机制已被研究。此外，使用4T1荷瘤小鼠模型评估了IrL在光照射下的肿瘤杀伤能力。这项工作为开发溶酶体靶向光敏剂/光氧化还原催化剂以克服缺氧肿瘤提供了策略。

A novel lysosome-targeted photosensitizer/photoredox catalyst based on cyclometalated Ir(III) complex IrL has been designed and synthesized, which exhibited excellent phosphorescence properties and the ability to generate single oxygen (1O2) and photocatalytically oxidize 1,4-dihydronicotinamide adenine dinucleotide (NADH) under light irradiation. Most importantly, the aforementioned activities are significantly enhanced due to protonation under acidic conditions, which makes them highly attractive in light-activated tumor therapy, especially for acidic lysosomes and tumor microenvironments. The photocytotoxicity of IrL and the mechanism of cell death have been investigated. Additionally, the tumor-killing ability of IrL under light irradiation was evaluated using a 4T1 tumor-bearing mouse model. This work provides a strategy for the development of lysosome-targeted photosensitizers/photoredox catalysts to overcome hypoxic tumors.