神经胶质瘤是原发性脑肿瘤，是最恶性的类型之一。成人型弥漫性胶质瘤可根据其组织学和分子特征分为 IDH 野生型胶质母细胞瘤、IDH 突变型星形细胞瘤、IDH 突变型和 1p/19q 编码缺失少突胶质细胞瘤。最近的研究表明，神经胶质瘤的每种亚型都有其特定的分布模式。然而，尽管有细胞起源等部分解释，但神经胶质瘤亚型特定分布的机制尚不完全清楚。为了研究多尺度大脑属性对神经胶质瘤分布的影响，我们基于 T1w 结构图像构建了弥漫性神经胶质瘤亚型的累积频率图，并评估了肿瘤频率与不同大脑属性之间的空间相关性，包括死后基因表达、功能连接指标、脑灌注、葡萄糖代谢和神经递质信号传导。构建回归模型来评估这些因素对不同神经胶质瘤亚型解剖分布的贡献。我们的研究结果表明，神经胶质瘤的三种不同亚型具有不同的分布模式，显示出对不同大脑环境属性的空间偏好。胶质母细胞瘤特别可能发生在富含突触相关通路和多种神经递质受体的区域。星形细胞瘤和少突胶质细胞瘤优先发生在富含与中性粒细胞介导的免疫反应相关的基因的区域。功能网络特征和神经递质分布也有助于少突胶质细胞瘤的分布。我们的结果表明，不同的大脑转录组、神经递质和连接组属性是决定神经胶质瘤亚型特定分布的因素。这些发现强调了在研究神经功能障碍时连接不同尺度的生物组织的重要性。© 2024 UICC。

Gliomas are primary brain tumors and are among the most malignant types. Adult-type diffuse gliomas can be classified based on their histological and molecular signatures as IDH-wildtype glioblastoma, IDH-mutant astrocytoma, and IDH-mutant and 1p/19q-codeleted oligodendroglioma. Recent studies have shown that each subtype of glioma has its own specific distribution pattern. However, the mechanisms underlying the specific distributions of glioma subtypes are not entirely clear despite partial explanations such as cell origin. To investigate the impact of multi-scale brain attributes on glioma distribution, we constructed cumulative frequency maps for diffuse glioma subtypes based on T1w structural images and evaluated the spatial correlation between tumor frequency and diverse brain attributes, including postmortem gene expression, functional connectivity metrics, cerebral perfusion, glucose metabolism, and neurotransmitter signaling. Regression models were constructed to evaluate the contribution of these factors to the anatomic distribution of different glioma subtypes. Our findings revealed that the three different subtypes of gliomas had distinct distribution patterns, showing spatial preferences toward different brain environmental attributes. Glioblastomas were especially likely to occur in regions enriched with synapse-related pathways and diverse neurotransmitter receptors. Astrocytomas and oligodendrogliomas preferentially occurred in areas enriched with genes associated with neutrophil-mediated immune responses. The functional network characteristics and neurotransmitter distribution also contributed to oligodendroglioma distribution. Our results suggest that different brain transcriptomic, neurotransmitter, and connectomic attributes are the factors that determine the specific distributions of glioma subtypes. These findings highlight the importance of bridging diverse scales of biological organization when studying neurological dysfunction.© 2024 UICC.