表观遗传学涉及不改变 DNA 序列本身的调控修饰，对于甲状腺癌的发生和进展至关重要。本研究旨在对甲状腺癌的表观遗传学研究领域进行全面分析，突出当前趋势、主要研究领域和潜在的未来方向。使用 Web of Science 核心合集 (WOSCC) 截至 11 月的数据进行了文献计量分析2023年1月1日。采用VOSviewer、CiteSpace和R包“bibliometrix”等分析工具进行全面的数据分析和可视化。这一过程确定了主要研究主题，以及对该领域做出贡献的有影响力的作者、机构和国家。分析显示，在过去二十年中，甲状腺癌表观遗传学研究显着增加。新兴的关键主题包括分子机制和生物标志物的探索、甲状腺癌的各种亚型、治疗干预的影响、技术和方法的进步以及转化研究的范围。这些主题内的研究热点突出了研究的密集领域和重大突破的潜力。本研究深入概述了甲状腺癌研究中表观遗传学的现状。它强调了表观遗传策略作为可行的治疗选择的潜力，并为研究人员和临床医生推进对这种复杂疾病的理解和治疗提供了宝贵的见解。未来的研究对于充分利用表观遗传学在甲状腺癌治疗中提供的治疗可能性至关重要。

Epigenetics, which involves regulatory modifications that do not alter the DNA sequence itself, is crucial in the development and progression of thyroid cancer. This study aims to provide a comprehensive analysis of the epigenetic research landscape in thyroid cancer, highlighting current trends, major research areas, and potential future directions.A bibliometric analysis was performed using data from the Web of Science Core Collection (WOSCC) up to November 1, 2023. Analytical tools such as VOSviewer, CiteSpace, and the R package "bibliometrix" were employed for comprehensive data analysis and visualization. This process identified principal research themes, along with influential authors, institutions, and countries contributing to the field.The analysis reveals a marked increase in thyroid cancer epigenetics research over the past two decades. Emergent key themes include the exploration of molecular mechanisms and biomarkers, various subtypes of thyroid cancer, implications for therapeutic interventions, advancements in technologies and methodologies, and the scope of translational research. Research hotspots within these themes highlight intensive areas of study and the potential for significant breakthroughs.This study presents an in-depth overview of the current state of epigenetics in thyroid cancer research. It underscores the potential of epigenetic strategies as viable therapeutic options and provides valuable insights for researchers and clinicians in advancing the understanding and treatment of this complex disease. Future research is vital to fully leverage the therapeutic possibilities offered by epigenetics in the management of thyroid cancer.