木糖葡萄球菌中通过自发 Oxa-Michael 加成实现吡嗪酮代谢物的结构多样化。
Structural Diversification of Pyrazinone Metabolites via Spontaneous Oxa-Michael Addition in Staphylococcus xylosus.
发表日期：2024 Jul 01
作者：
Ju Ryeong Lee, Su Jung Hwang, Yukyung Choi, Jonghwan Kim, Gyu Sung Lee, Bum Soo Lee, Ki Hyun Kim, Kyo Bin Kang, Hyo-Jong Lee, Chung Sub Kim
来源：
JOURNAL OF NATURAL PRODUCTS
摘要：
从木糖葡萄球菌 ATCC 29971 中鉴定出一系列吡嗪酮代谢物 (1-11)。其中六种被羟基化或甲氧基化，这些代谢物被认为是通过与水或甲醇分子进行罕见的非催化 oxa-Michael 加成反应产生的。证实异丙醇也可以作为反应的迈克尔供体。 1-7和合成前体2a显示出对乳腺癌细胞迁移的显着抑制。
A family of pyrazinone metabolites (1-11) were characterized from Staphylococcus xylosus ATCC 29971. Six of them were hydroxylated or methoxylated, which were proposed to be produced by the rare noncatalytic oxa-Michael addition reaction with a water or methanol molecule. It was confirmed that isopropyl alcohol can also be the Michael donor of the reaction. 1-7 and the synthetic precursor 2a showed significant inhibition of breast cancer cell migration.