使用多组学方法探索核因子 E2 相关因子 2 抗氧化反应元件 (Nrf2-ARE) 信号通路中的基因，以了解早期激素受体阳性乳腺癌绝经后妇女癌症相关疲劳 (CRF) 变异性的关系从宾夕法尼亚州西部招募患有早期激素受体阳性乳腺癌的绝经后妇女 (N = 116)。研究了 Nrf2-ARE 途径的候选基因与 CRF 发生和严重程度的关系。使用逻辑回归来评估发生率，使用线性回归来评估严重性。NFE2L2 中的 rs2706110 TT 基因型与 CRF 发生几率增加 3.5 倍相关。 PRDX1 中的胞嘧啶-磷酸-鸟嘌呤 (CpG) 位点 cg22820568 与 CRF 的发生和严重程度相关。基于 Nrf2-ARE 基因的生物标志物可能有助于识别患有更严重 CRF 的风险增加的女性，并制定有针对性的干预措施。

To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer.Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania.Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity.The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity.Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.