结直肠癌（CRC）对放射治疗和化疗等传统治疗方式的耐药性以及相关的副作用，极大地限制了有效的抗癌策略。大量表观遗传学研究表明，天然存在的芪可以修饰或逆转异常的表观遗传学改变，特别是异常的 DNA 甲基化状态，为预防或治疗 CRC 提供潜在途径。通过调节 DNA 甲基化机制组件的活性，植物化学物质可能通过多种分子机制影响 CRC 癌变的各个阶段。几项表观遗传学研究，特别是临床前研究，强调了二苯乙烯的有效 DNA 甲基化调节作用，且对生物体的副作用最小，特别是在 CRC 联合治疗中。然而，目前关于常见的二苯乙烯类化合物对结直肠癌的影响的现有临床前和临床数据有限。因此，有必要进行额外的表观遗传学研究来探索这些植物化学物质在 CRC 发展中的预防潜力，并验证它们在预防和治疗 CRC 中的治疗应用。本综述旨在概述选定的生物活性二苯乙烯作为 CRC 的潜在化学预防剂，重点关注其作用调节机制，特别是针对 CRC 中 DNA 甲基化机制的改变。

The resistance of colorectal cancer (CRC) to conventional therapeutic modalities, such as radiation therapy and chemotherapy, along with the associated side effects, significantly limits effective anticancer strategies. Numerous epigenetic investigations have unveiled that naturally occurring stilbenes can modify or reverse abnormal epigenetic alterations, particularly aberrant DNA methylation status, offering potential avenues for preventing or treating CRC. By modulating the activity of the DNA methylation machinery components, phytochemicals may influence the various stages of CRC carcinogenesis through multiple molecular mechanisms. Several epigenetic studies, especially preclinical research, have highlighted the effective DNA methylation modulatory effects of stilbenes with minimal adverse effects on organisms, particularly in combination therapies for CRC. However, the available preclinical and clinical data regarding the effects of commonly encountered stilbenes against CRC are currently limited. Therefore, additional epigenetic research is warranted to explore the preventive potential of these phytochemicals in CRC development and to validate their therapeutic application in the prevention and treatment of CRC. This review aims to provide an overview of selected bioactive stilbenes as potential chemopreventive agents for CRC with a focus on their modulatory mechanisms of action, especially in targeting alterations in DNA methylation machinery in CRC.